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Research: Dr. Letarte’s laboratory concentrates on vascular diseases caused by mutations in genes coding for receptors of the transforming growth factor beta superfamily. Her team focuses primarily on the proteins endoglin and ALK1, which are specifically expressed on endothelial cells. Endothelial cells line the blood vessels and provide oxygen and nutrients to all tissues. Dr. Letarte’s research team aims to understand how these mutations lead to specific vascular diseases. In particular, they hope to gain a better understanding of the structure and function of endoglin in cells and animal models, using a variety of molecular, cellular and immunological techniques. They are also working to characterize new endothelial cell pathways that are defective in vascular disease. Recent studies have found that a soluble form of endoglin is associated with preeclampsia, a pregnancy disorder that complicates five per cent of pregnancies.
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JOURNAL OF CLINICAL MEDICINEno. 11 (2020): 3571
Takako Saitô, Marcel Bokhove, Romina Croci,Sara Zamora-Caballero,Ling Han,Michelle Letarte, Daniele de Sanctis,Luca Jovine
The Japanese Biochemical Society/The Molecular Biology Society of Japan (2017)
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