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个人简介
Professor Mihai G. Netea is one of the leading scientists working in the fi eld of infl ammation
research. He was trained as a physician and clinical investigator with a strong interest in basic
medical research. He completed his PhD training in 1998 and then went on to work as postdoctoral
research fellow, and later as internist-infectologist in the Department of Internal Medicine at
Radboud University Nijmegen, NL. In 2007 he was a visiting scientist in the Division of Infectious
Diseases, at the University of Colorado Health Sciences Centre, Denver and then became a
professor of experimental medicine in Nijmegen.
Professor Netea made several important discoveries that contributed signifi cantly to the
understanding of innate immunity. His laboratory described that the innate arm of our immune
system can be trained to gain function. His group also demonstrated that a homozygous mutation
of dectin-1 leads to a mild form of chronic mucocutaneous candidiasis and trichophytosis. In
addition, they published that genes regulating innate immunity (TLRs etc.) are under selection
pressure and showed that interleukin-18 has profound metabolic effects. Using mutated Candida
Albicans and blockade of PRRs, they demonstrated the relative importance of the various ligands
and receptors. Professor Netea published a large number of excellent articles in leading scientifi c
journals including The New England Journal of Medicine, Nature Medicine, PNAS or Blood.
He received several prestigious awards and honors including: Institute of Cellular Signaling
Nijmegen Award (1997); Merck Irving S. Sigal Memorial Award of the American Academy of
Microbiology (1999); International Sepsis Forum Young Investigator Award (2002); Postdoctoral
Investigator Award, International Cytokine Society (2003); ICAAC Programme Committee Award
(2005); Vidi Research Award (2005; 2010); Radboud Science Award (2011); ERC Consolidator
Grant (2012).
Based on his outstanding contributions the ESCI Council is proud to select Professor Netea as the
recipient of the 2013 ESCI Award for Excellence in Clinical Research.
Selected publications:
• Frank L. van de Veerdonk, Renoud J. Marijnissen, Bart Jan Kullberg, Hans J. P. M. Koenen, Shih-Chin Cheng, Irma Joosten, Wim B. van den Berg, David L. Williams, Jos W. M. van der Meer, Leo A. B. Joosten, Netea MG. . The macrophage mannose receptor induces IL-17 in response to Candida albicans. . Cell Host and Microbe, 2009.
• Netea MG, Nold-Petry CA, Nold MF, Joosten LA, Opitz B, van der Meer JH, van de. Differential requirement for the activation of the inflammasome for processing. Blood, 2009.
• Netea MG, Brown GD, Kullberg BJ, Gow NA. . An integrated model of the recognition of Candida albicans by the innate immune. Nature Reviews Microbiology, 2008.
• Ferwerda B, McCall MB, Alonso S, .. ., Netea MG. TLR4 polymorphisms, infectious diseases, and evolutionary pressure during. PNAS, 2007.
Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes. Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Ifrim DC, Saeed S, Jacobs C, van Loenhout J, de Jong D, Stunnenberg HG, Xavier RJ, van der Meer JW, van Crevel R, Netea MG. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17537-42
STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. van de Veerdonk FL, Plantinga TS, Hoischen A, Smeekens SP, Joosten LA, Gilissen C, Arts P, Rosentul DC, Carmichael AJ, Smits-van der Graaf CA, Kullberg BJ, van der Meer JW, Lilic D, Veltman JA, Netea MG.N Engl J Med. 2011 Jul 7;365(1):54-61
研究兴趣
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