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新生隐球菌是条件致病性真菌,经呼吸道吸入后在肺部可形成结节;释放进入血液后,新生隐球菌穿越血脑屏障引起脑膜炎,危害严重。以新生隐球菌为模式生物,我们主要研究真菌与免疫细胞(巨噬细胞、中性粒细胞等)的相互作用及其穿越血脑屏障的机制。真菌、螨虫和呼吸道合胞病毒等是重要的变应原。我们制备过敏性哮喘模型,探究其发生机制(T淋巴细胞、上皮细胞等)和诊断治疗方法。气道重塑是哮喘和COPD等基本病理特征。通过制备COPD和BPD等疾病模型,我们探讨肺发育及气道重塑的发生机制。此外,我们也有兴趣探讨椎板切除术后瘢痕增生以及心肌重塑等器官纤维化的发生机制。依托南京医科大学国家卫生健康委员会抗体技术重点实验室,我们研究和开发全人治疗性抗体。项目组与临床团队密切合作,期待为疾病的预防、诊断和治疗提供新的靶标和策略。
Research Interests
Papers共 107 篇Author StatisticsCo-AuthorSimilar Experts
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Inflammation and regenerationno. 1 (2024)
Xing Wu, Jiayan Shen, Jinjin Liu,Nannan Kang,Mingshun Zhang,Xinyu Cai, Xin Zhen,Guijun Yan, Yang Liu, Haixiang Sun
Biology of reproduction (2024)
Clinical kidney journalno. 1 (2024): sfad277-sfad277
Min Wang, Manni Zhu, Xinyu Jia,Jingjing Wu,Qi Yuan,Tingting Xu,Zhengxia Wang,Mao Huang, Ningfei Ji,Mingshun Zhang
International Immunopharmacology (2024): 112680
Scientific Reportsno. 1 (2024)
Qi Yuan, Xinyu Jia,Min Wang,Zhongqi Chen,Tingting Xu,Xijie Zhang, Yanan Liu,Zhengxia Wang,Chen Yang,Mingshun Zhang,Wei Zhang,Mao Huang,Ningfei Ji
Allergy, asthma & immunology researchno. 4 (2024): 422-433
Clinical and translational scienceno. 3 (2024)
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Author Statistics
#Papers: 106
#Citation: 1291
H-Index: 23
G-Index: 32
Sociability: 6
Diversity: 3
Activity: 42
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