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The ability to escape from surveillance by the immune system is regarded as one of the essential hallmarks of cancer cells. While the functions of lymphocytes (T, B and NK cells) in tumor immunosurveillance have been studied for decades, the roles of macrophages on tumor cell elimination have only begun to be explored. Macrophages detect and eliminate tumor cells via a process of macrophage-mediated cell phagocytosis called “programmed cell removal” (PrCR). Recent studies showed that blockade of a “don't eat me” signal CD47 on malignant hematopoietic and various solid tumor cells enabled their phagocytosis by macrophages and prevented their engraftment in mice lacking T, B and NK cells, indicating a key role of macrophages in tumor surveillance and elimination. While inducing macrophage-mediated immunosurveillance holds considerable promise for the treatment of various cancers, its underlying mechanism remains largely unknown.
My laboratory is focused on three fundamental questions: First, how do macrophages recognize tumor cells and target them for phagocytosis? Second, at different stages of cancer development, do macrophages exert multiple layers of extrinsic PrCR pressure to tumor cells, and how do tumor cells react and develop self-protective mechanisms? Third, what are the intrinsic regulatory programs in macrophages that regulate their functions in PrCR?
My laboratory is focused on three fundamental questions: First, how do macrophages recognize tumor cells and target them for phagocytosis? Second, at different stages of cancer development, do macrophages exert multiple layers of extrinsic PrCR pressure to tumor cells, and how do tumor cells react and develop self-protective mechanisms? Third, what are the intrinsic regulatory programs in macrophages that regulate their functions in PrCR?
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Nature Structural & Molecular Biologyno. 3 (2024): 465-475
Cell Insightno. 2 (2024): 100150-100150
Nicole M. Mattson,Anthony K. N. Chan,Kazuya Miyashita,Elizaveta Mukhaleva,Wen-Han Chang,Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li,Qiao Liu,Xiaobao Xu,
Nature Structural & Molecular Biologyno. 3 (2024): 465-475
Zahir Shah, Lei Tian, Zhixin Li, Lewei Jin,Jianying Zhang,Zhenlong Li,Tasha Barr, Hejun Tang,Mingye Feng,Michael A. Caligiuri,Jianhua Yu
Cancer Researchno. 7_Supplement (2023): 6234-6234
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Linh T. Bui,Xu Cao,Jinhui Wang, Fan Meng,Mingye Feng,Leonidas Arvanitis,Rifat Mannan,Yanghee Woo,Kamran Idrees, Nicholas E. Banovich,Mustafa Raoof
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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JCI INSIGHTno. 14 (2023)
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CANCER RESEARCHno. 7 (2023)
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Research squareno. 1 (2023): 5706-12
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