基本信息
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Career Trajectory
Bio
After studying ecology at university, graduating in 1978, I quickly switched to biochemical pathway analysis, establishing under Rod Quayle's supervision the methanol pathway in yeasts and its regulation under conditions of mixotrophy where I picked up an interest in metabolic flux analysis. Later went on to look at hydrocarbon assimilation before returning to methanol metabolism in anaerobic bacteria as part of a Royal Society Fellowship Award. This was also the time I switched from UK to France and started a journey which was to last more than 30 years, developing microbial physiology of industrial micro-organisms creating the metabolic engineering group in 1991, working predominantly with lactic acid bacteria and amino-acid producing corynebacteria. This led to an interest in systems biology and the global regulatory aspects controlling metabolic networks as genomic technology became available. In 2004 I was apponted as executive Director of the Toulouse Biotechnology laboratory and remained in this role until end of 2015 building the lab into an A+ rated centre of excellence. During this time my research shifted to looking at how to improve vaccine development, but I also headed up the CRITT BioIndustries structure, an offshoot from the lab dealing with technology transfer, notably to SMEs, and later the Toulouse Genome platforms, and a small startup-like structure dealing with flow chemistry (MEPI). In 2016, looking for a change to refresh the scientific input after gradually getting involved in too much administrative work, I moved to Singapore to setup and lead a new initiative: the AStar Biotransformation Innovation Programme which rapidly involved into a industry-facing multi-disciplinary platform spanning molecular discovery, metabolic engineering and fermentation to generate high value-added metabolites for the food, flavour and consumer care industrial sectors. This role was rapidly expanded with a joint appointment to take on the supervision and strategic restructuring of the Microbial Biotechnology division of the nearby AStar Institue of Chemical & Engineering Sciences laboratory. Throughout this trajectory the guiding principle has always been that application-driven science has to be knowledge-based and that the underpinning science input must be top quality. This has led to multiple collaborations with industry both in project development but also as a consultant. In addition have sat on numerous international evaluation boards and SABs, learning a great deal in the process. The logic has always ben to bring out the best of those working under my supervision and to avoid any complacency creeping up as in the competitive world of research, relaxing the effort leads immediately to going backwards: fortunately my co-workers have been top quality facilitating this effort.
Research Interests
Papers共 61 篇Author StatisticsCo-AuthorSimilar Experts
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AT Huser,C Chassagnole,ND Lindley,M Merkamm,A Guyonvarch,V Elisakova, M Patek,J Kalinowski,I Brune,A Puhler,A Tauch
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Author Statistics
#Papers: 61
#Citation: 2443
H-Index: 30
G-Index: 49
Sociability: 5
Diversity: 3
Activity: 1
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