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His early career at the Pasteur Institute focused on brain nicotinic receptors and their role in tobacco addiction, using both experimental and computational approaches. He moved to systems biology while modeling bacterial chemotaxis at the University of Cambridge (UK).
His research then centred on inter and intra-cellular signals, with a particular emphasis on synaptic plasticity,first at EMBL-EBI and then at the Babraham Institute. He coordinated the development of key software tools to support computational systems biology research, such as BioModels, and was a major figure behind the development of a coordinated
set of standards, including SBML, SBGN and the MIRIAM guidelines. He is associate editor of BMC Systems Biology and NPJ Systems Biology and Applications.
His research then centred on inter and intra-cellular signals, with a particular emphasis on synaptic plasticity,first at EMBL-EBI and then at the Babraham Institute. He coordinated the development of key software tools to support computational systems biology research, such as BioModels, and was a major figure behind the development of a coordinated
set of standards, including SBML, SBGN and the MIRIAM guidelines. He is associate editor of BMC Systems Biology and NPJ Systems Biology and Applications.
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