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个人简介
My research career has focused on understating the molecular mechanisms that maintain the stability of the genome, specifically during the process of DNA replication. Throughout my career, I have gained extensive training in genetics, biochemistry and molecular and cellular biology.
During my PhD at CABIMER (Sevilla, Spain), I investigated the role of manganese homeostasis on genome instability and cell cycle using yeast as model organism (JBC, 2012 and 2015). Furthermore, in collaboration with Prof. Andrés Aguilera, I uncovered an unexpected role of RNA:DNA hybrids in origin-independent replication initiation within the ribosomal DNA locus (PNAS, 2015). During this time, I also carried out 2 international research stays (USA and France).
Afterwards, I moved as postdoc to the recognised laboratory of Prof. Helle Ulrich at IMB (Mainz, Germany). During this time, I conducted a self-dependent investigation that led to the discovery of a novel mechanism of checkpoint activation upon replication stress in yeast cells, which involves resection at ssDNA gaps behind replication forks (The EMBO Journal, 2018). This article merited a comment article on the same journal. I also uncovered a new function of the helicase Pif1 in the template switching pathway of DNA damage bypass, signing the article as corresponding author (NAR, 2018), and I investigated how DNA damage processing is coordinated with genome replication (Mol Cell, 2020). Furthermore, I established a fruitful collaboration (EMBO Rep, 2021) and I also produced a review article and a book chapter on the DNA replication and replication stress topics (Front Genet, 2016; Methods Enzymol, 2019).
In 2018, I was awarded with a very competitive Marie Curie IF grant to continue my work at CABIMER (Sevilla, Spain) in the lab of Prof. Pablo Huertas, where I am establishing my own line of research on the mechanism of checkpoint activation and DNA damage tolerance during replication of damaged template on human cell lines. Increasing evidence points out that replication forks do not permanently stall upon encountering DNA lesions but re-start downstream of the lesion, thus generating single strand (ss)DNA gaps. Over the next years, my research efforts will be focused on the study of ssDNA gaps processing and its relevance on human diseases such as cancer.
After more than 10 years of research experience in highly-ranked national and international institutions, I have published in some of the top scientific journals and I have proven my capacity to independently lead a research project (corresponding author of the last 2 publications) and secure funding from international (H2020-Marie Curie Actions) and national competitive calls. I have regularly presented my work at international conferences and have established fruitful collaborations.
研究兴趣
论文共 18 篇作者统计合作学者相似作者
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Daniel Salas-Lloret,Néstor García-Rodríguez, Emily Soto-Hidalgo, Lourdes González-Vinceiro, Carmen Espejo-Serrano, Lisanne Giebel, María Luisa Mateos-Martín,Arnoud H. de Ru,Peter A. van Veelen, Pablo Huertas,Alfred C. O. Vertegaal,Román González-Prieto
Nature Communicationsno. 1 (2024): 1-14
Daniel Salas-Lloret,Néstor García-Rodríguez, Emily Soto-Hidalgo, Lourdes González-Vinceiro, Carmen Espejo-Serrano, Lisanne Giebel, María Luisa Mateos-Martín,Arnoud H. de Ru,Peter A. van Veelen,Pablo Huertas,Alfred C. O. Vertegaal,Román González-Prieto
Nature Communicationsno. 1 (2024): 1-14
Daniel Salas-Lloret,Néstor García-Rodríguez, Emily Soto-Hidalgo, Lourdes González-Vinceiro, Carmen Espejo-Serrano, Lisanne Giebel, María Luisa Mateos-Martín,Arnoud H de Ru,Peter A van Veelen,Pablo Huertas,Alfred C O Vertegaal,Román González-Prieto
Nature communicationsno. 1 (2024): 4292-4292
Nucleic acids research (2024)
Daniel Salas-Lloret,Néstor García-Rodríguez, Emily Soto-Hidalgo, Lourdes González-Vinceiro, Carmen Espejo-Serrano, Lisanne Giebel, María Luisa Mateos-Martín,Arnoud H. de Ru,Peter A. van Veelen, Pablo Huertas,Alfred C. O. Vertegaal,Román González-Prieto
Nature Communicationsno. 1 (2024)
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