基本信息
浏览量:0
职业迁徙
个人简介
The current worldwide diabetes epidemic has stimulated research to find ways to increase pancreatic beta cell mass and/or to decrease beta cell death. Focus of my research is to find ways to induce the growth, survival, and regeneration of functioning pancreatic beta cells in vivo. I have focused on the role of growth factors and the signaling and molecular pathways through which they mediate their effects in normal pancreatic beta cell physiology and in the pathophysiological settings of diabetes and islet transplantation. The translational goals of my research are: i) to induce human beta cell growth and function including in the setting of islet transplants; ii) to induce beta cell regeneration in vivo; iii) and to improve outcomes in animal models of type 1 and/or type 2 diabetes, either through the acute use of growth factors or downstream target molecules activated by these factors. The ultimate objective of the research is to find ways to enhance preservation and regeneration of functional beta cells in vivo, for the treatment of diabetes.
My recent focus is on the role of extracellular vesicles (EVs) derived from the circulation of patients with type 1 diabetes. Particularly, our goal is to examine how circulating EVs at different stages of type 1 diabetes are cytotoxic to beta cell health and induce pro-inflammatory phenotype in immune cells, to identify the distinct cargo in the EVs that mediates its functional effects, and ultimately to investigate their potential as disease biomarkers.
研究兴趣
论文共 23 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Joanna Filipowska, Zelda Cisneros,Nancy Leon-Rivera,Peng Wang,Randy Kang,Geming Lu, Yate-Ching Yuan,Supriyo Bhattacharya,Sangeeta Dhawan,Adolfo Garcia-Ocaña,Nagesha Guthalu Kondegowda,Rupangi C Vasavada
bioRxiv : the preprint server for biology (2024)
Joanna Filipowska, Zelda Cisneros,Nancy Leon-Rivera,Peng Wang,Randy Kang,Geming Lu, Yate-Ching Yuan,Supriyo Bhattacharya,Sangeeta Dhawan,Adolfo Garcia-Ocana,Nagesha Guthalu Kondegowda,Rupangi C Vasavada
crossref(2024)
SCIENCE ADVANCESno. 44 (2023)
加载更多
作者统计
#Papers: 23
#Citation: 341
H-Index: 8
G-Index: 12
Sociability: 4
Diversity: 2
Activity: 5
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn