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Neurological illnesses such as Autism Spectrum disorders, schizophrenia and epiliepsy are thought to arise during development of the nervous system
Increasing experimental evidence suggests that an imbalance between excitatory and inhibitory activity within the brain is a critical factor in the etiology of these illnesses. Our laboratory is currently investigating the interaction between electrical activity and genetic programs in early brain development with an emphasis on inhibitory neurons. We use the mouse as a genetically tractable mammalian model system.
In the short term, we hope to elucidate the type and source of electrical activity responsible for interneuron development. We are exploring the role of neurotransmitters such as glutamate and gamma-aminobutyric acid (GABA) in the regulation of interneuron maturation. In addition, we are studying the contribution of glutamate and GABA receptors for the establishment of neuronal morphology during development. We use viral tracing techniques, electrophysiology and mouse genetics to probe developing circuits and manipulate their activity patterns.
Ultimately, we hope to reveal the emergent connectivity of different interneuron subtypes as they become integrated into nascent cortical circuits. We are interested in understanding the mechanisms by which neuronal activity controls the assembly of these developing circuits and how the disruption of such assembly contributes to the pathogenesis of an array of neurological disorders.
Increasing experimental evidence suggests that an imbalance between excitatory and inhibitory activity within the brain is a critical factor in the etiology of these illnesses. Our laboratory is currently investigating the interaction between electrical activity and genetic programs in early brain development with an emphasis on inhibitory neurons. We use the mouse as a genetically tractable mammalian model system.
In the short term, we hope to elucidate the type and source of electrical activity responsible for interneuron development. We are exploring the role of neurotransmitters such as glutamate and gamma-aminobutyric acid (GABA) in the regulation of interneuron maturation. In addition, we are studying the contribution of glutamate and GABA receptors for the establishment of neuronal morphology during development. We use viral tracing techniques, electrophysiology and mouse genetics to probe developing circuits and manipulate their activity patterns.
Ultimately, we hope to reveal the emergent connectivity of different interneuron subtypes as they become integrated into nascent cortical circuits. We are interested in understanding the mechanisms by which neuronal activity controls the assembly of these developing circuits and how the disruption of such assembly contributes to the pathogenesis of an array of neurological disorders.
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论文共 5 篇作者统计合作学者相似作者
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Maria Carmen Inda,Suhasini Joshi,Tai Wang,Alexander Bolaender,Srinivasa Gandu,John Koren III,Alicia Yue Che,Tony Taldone,Pengrong Yan,Weilin Sun,Mohammad Uddin,Palak Panchal,Matthew Riolo,Smit Shah,Afsar Barlas,Ke Xu,Lon Yin L. Chan, Alexandra Gruzinova,Sarah Kishinevsky,Lorenz Studer,Valentina Fossati,Scott A. Noggle,Julie R. White,Elisa de Stanchina,Sonia Sequeira, Kyle H. Anthoney,John W. Steele,Katia Manova-Todorova,Sujata Patil,Mark P. Dunphy,NagaVaraKishore Pillarsetty, Ana C. Pereira,Hediye Erdjument-Bromage,Thomas A. Neubert, Anna Rodina,Stephen D. Ginsberg,Natalia De Marco Garcia,Wenjie Luo,Gabriela Chiosis
Neuroscience (2018): 23-35
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#Papers: 5
#Citation: 311
H-Index: 5
G-Index: 5
Sociability: 4
Diversity: 2
Activity: 4
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