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Our work focuses on atherosclerosis-related signal transduction and the genetic bases of atherosclerosis and vein graft failure, both in vitro and in vivo. We investigate the regulation of receptor protein tyrosine kinases by G protein-coupled receptor kinases (GRKs), and the role of GRKs and β-arrestins in atherosclerosis; the role of tumor necrosis factor and its receptors in atherosclerosis; and the role of the dual Rho-GEF kalirin in atherosclerosis. For in vivo modeling of atherosclerosis and neointimal hyperplasia, we use mouse carotid artery bypass grafting with either veins or arteries from gene-deleted or congenic wild type mice, as well as aortic atherosclerosis studies and bone marrow transplantation. To study receptor phosphorylation, signal transduction, and intracellular trafficking, we employ primary smooth muscle cells, endothelial cells, and macrophages derived from knockout mice or treated with RNA interference.
Key Words: atherosclerosis, G protein-coupled receptor kinases, arrestins, desensitization, phosphorylation, platelet-derived growth factor receptors, receptor protein tyrosine kinases, smooth muscle cells, neointimal hyperplasia, Rho-GEF.
Key Words: atherosclerosis, G protein-coupled receptor kinases, arrestins, desensitization, phosphorylation, platelet-derived growth factor receptors, receptor protein tyrosine kinases, smooth muscle cells, neointimal hyperplasia, Rho-GEF.
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Lisheng Zhang,Jiao-Hui Wu,Pierre-Yves Jean-Charles, Pavitra Murali, Wenli Zhang, Aeva Jazic,Suneet Kaur,Igor Nepliouev,Jonathan A. Stiber,Kamie Snow,Neil J. Freedman,Sudha K. Shenoy
Lisheng Zhang,Jiao-Hui Wu,Pierre-Yves Jean-Charles, Pavitra Murali, Wenli Zhang,Aeva Jazic,Suneet Kaur,Igor Nepliouev,Jonathan A Stiber,Kamie Snow,Neil J Freedman,Sudha K Shenoy
The Journal of biological chemistryno. 7 (2023): 104911-104911
Lisheng Zhang,Jiao-Hui Wu,Tai-Qin Huang,Igor Nepliouev,Leigh Brian,Zhushan Zhang, Nathan P Rudemiller, Steven D Crowley,Neil J Freedman,Jonathan A Stiber
Arteriosclerosis, Thrombosis, and Vascular Biologyno. suppl_1 (2017)
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