基本信息
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职业迁徙
个人简介
The goal of my research program is to answer one of the biggest fundamental questions in life science: What causes human aging? In addition to answering this key question, we also aim to understand why aging is the primary risk factor for human chronic diseases. The degenerative protein modifications (DPMs) occur via spontaneous protein modifications (e.g., oxidation, deamidation, glycation) have long been recognized as important mediators of human aging, but the underlying mechanisms by which they impair tissue and organ function have remained elusive. This is largely due to the current technical challenges of performing systems-wide analysis of progressive molecular damage in complex human bio samples. My laboratory is therefore focused on developing advanced ‘omics approach to elucidating DPM-biology in health and diseases, generating DPM-specific mAb to investigating functional consequences of DPMs accumulation in tissues, and targeting DPM to advancing immunotherapy for age-linked diseases. The ultimate aim of our research is to develop novel therapeutic and prophylactic approaches to combat the healthcare burden of age-related chronic diseases affecting the aging global population.
Research Interests
Developing new approaches to elucidating molecular mechanisms of health and disease.
Understanding degenerative protein modifications as molecular mediators of biological aging.
Advancing immunotherapy for cardiovascular disease by targeting isoDGR-modified proteins.
Identifying new drug targets for cancer therapy and tumour prevention.
Defining molecular mediators underpinning early asymptomatic neurodegeneration.
Research Interests
Developing new approaches to elucidating molecular mechanisms of health and disease.
Understanding degenerative protein modifications as molecular mediators of biological aging.
Advancing immunotherapy for cardiovascular disease by targeting isoDGR-modified proteins.
Identifying new drug targets for cancer therapy and tumour prevention.
Defining molecular mediators underpinning early asymptomatic neurodegeneration.
研究兴趣
论文共 318 篇作者统计合作学者相似作者
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引用量
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期刊级别
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合作机构
International journal of molecular sciencesno. 4 (2024): 1950-1950
Journal of cardiovascular development and diseaseno. 7 (2024): 196-196
Darren Mun Yoong Choy,Bryan Chin Hou Ang,Sunil S. Adav, Yu Bo Zheng, Caius Jun Shyan Goh,Jin Wei, Arjunan Kumaran,Chun Hau Chua,Nicola Yian Gan,Siu Kwan Sze, Leonard Wei Leon Yip
Journal of Biomedical Scienceno. 1 (2024): 1-21
Proceedings of the National Academy of Sciences of the United States of Americano. 25 (2023)
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作者统计
#Papers: 317
#Citation: 13988
H-Index: 59
G-Index: 108
Sociability: 7
Diversity: 0
Activity: 2
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