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My research is focused on molecular recognition in biocatalysis, enzyme inhibition and signal transduction. We study the interaction of ligands and proteins via X-ray crystallography, binding assays, kinetics as well as biophysical and spectroscopic techniques. A main aim is to characterize the molecular principles of interaction leading to specificity, catalysis as well as conformational changes such as domain motions. This information is used to understand the mode of action of enzymes, receptors and other proteins and also to apply it to structure-based rational design of novel biocatalysts and pharmacologically relevant protein inhibitors. In addition to experimental methods, computational tools are a key method to rationalize structure-function relationships as well as for enzyme or inhibitor design.
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Tobias Claff, Andhika B. Mahardhika,Victoria J. Vaaßen,Jonathan G. Schlegel,Christin Vielmuth,Renato H. Weiße,Norbert Sträter,Christa E. Müller
Rabea Voget, Julian Breidenbach,Tobias Claff, Alexandra Hingst, Katharina Sylvester, Christian Steinebach,Lan Phuong Vu,Renato H. Weiße,Ulrike Bartz,Norbert Sträter, Christa E. Müller,Michael Gütschow
Angewandte Chemie (International ed. in English)no. 17 (2023)
Cell reportsno. 7 (2023): 112679-112679
Julia Kratky,Daniel Eggerichs,Thomas Heine,Sarah Hofmann, Philipp Sowa, R.H.-J. Weisse,Dirk Tischler,Norbert Sträter
Angewandte Chemieno. 17 (2023)
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Communications Chemistryno. 1 (2023): 1-10
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Shenghua Gao,Letian Song,Katharina Sylvester,Beatrice Mercorelli,Arianna Loregian,Karoly Toth,Renato H. Weisse, Abibe Useini,Norbert Straeter, Mianling Yang,Bing Ye,Ann E. Tollefson,
JOURNAL OF MEDICINAL CHEMISTRYno. 23 (2023): 16426-16440
Tobias Claff,Jonathan Schlegel,Victoria Vaaßen,Jan Voss,Renato Weisse,Robert Cheng, Sandra Markovic-Mueller,Denis Bucher,Norbert Sträter,Christa Müller
Research Square (Research Square) (2023)
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