基本信息
浏览量:10
职业迁徙
个人简介
Genetics of Clostridium difficile I was the first to develop methods for the genetic analysis of this important pathogen (in 1994). These methods are still in use by my research group and other workers around the world. My current work on C. difficile is aimed at determining the molecular basis for its ability to cause disease. It is essential to understand this if more effective methods for the treatment of C. difficile induced disease are to be developed. * Molecular biology of conjugative transposons. These are highly promiscuous gene transfer elements which are important in the spread of antibiotic resistance. I have a range of projects on these elements from epidemiology in model systems to understanding the mechanism of transfer of these elements at the molecular level. My research group is also developing these elements as tools for the genetic manipulation of different bacteria. * Metagenomics This is a relatively new approach which aims to characterise all the genomes in a particular environmental niche. My group has begun an analysis of the metagenome of the oral cavity. As approximately half of the organisms in the oral cavity can not be cultured their contribution to health and disease is difficult to understand. Metagenomics is a tool that will allow us to begin to understand the role of these non-cultivable organisms. The (very) long term aim of this project is to characterise all the organisms in the oral cavity. It is also planned to investigate the metagenomes of other human sites such as the vagina and the gut.
研究兴趣
论文共 90 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Microbial genomicsno. 3 (2023)
CRC Press eBooks (2022)
引用0浏览0引用
0
0
CRC Press eBooks (2022)
Md. Ajijur Rahman,Frank Kaiser,Shirin Jamshidi, Marta Freitas Monteiro,Khondaker Miraz Rahman,Peter Mullany,Adam P. Roberts
biorxiv(2020)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn