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Dr. Peter Zandstra’s work integrates engineering and biological approaches to the growth and differentiation of adult embryonic stem cells. His lab focuses largely on stem cell bioengineering to develop descriptions of stem cell fate processes, and to use this information in the design and implementation of stem cell-based technologies. His research aims to understand the interface between microenvironmental control and the intracellular networks that underlie stem cell fate decisions. Dr. Zandstra is motivated by the hypothesis that appropriate engineering of the cellular microenvironment will enable the manipulation of stem cell self-renewal and differentiation. Using bioengineering strategies such as mathematical modeling, microfabrication and bioreactors, his team’s work is applied to the control of embryonic stem cell self-renewal, bioprocesses generating blood and cardiac cells from embryonic stem cells, and control of intercellular signaling networks to grow human blood stem cells. This work has contributed to the development of clinically and industrially relevant and academically recognized technologies based on the design of bioprocesses for the growth and differentiation of adult and embryonic stem cells. Direct applications of this work include tissue engineering and cellular therapies. Dr. Zandstra is an active member of the HSRLCE leading multidisciplinary operating grants in the exciting area of cardiovascular regeneration.
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论文共 93 篇作者统计合作学者相似作者
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Judith Elbaz,Mira C Puri,Maryam Faiz,K W Annie Bang, Lena Nguyen, Bar Makovoz,Marina Gertsenstein,Samer M I Hussein,Peter W Zandstra,Laurent Briollais,Nika Shakiba,Andras Nagy
biorxiv(2020)
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