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Many cancer cells present numerical chromosomal abnormalities such as aneuploidy and/or polyploidy. Since the segregation of the genomic material occurs during cell division, an understanding of the mechanisms that control mitosis can unveil some of the processes that promote tumour onset and development. Moreover, one of the hallmarks of cancer is uncontrolled cell proliferation and many cell division regulators are validated targets for the isolation of novel chemotherapeutic drugs for the treatment of cancer pathologies. The goal of our research project is to understand some of the molecular mechanisms that control the last phase of cell division – cytokinesis – and to identify novel gene products that functions in this process in metazoans.
Many cancer cells present numerical chromosomal abnormalities such as aneuploidy and/or polyploidy. Since the segregation of the genomic material occurs during cell division, an understanding of the mechanisms that control mitosis can unveil some of the processes that promote tumour onset and development. Moreover, one of the hallmarks of cancer is uncontrolled cell proliferation and many cell division regulators are validated targets for the isolation of novel chemotherapeutic drugs for the treatment of cancer pathologies. The goal of our research project is to understand some of the molecular mechanisms that control the last phase of cell division – cytokinesis – and to identify novel gene products that functions in this process in metazoans.
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