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Area of Research
Ping Lee’s research focuses on developing new approaches, including the study of mechanisms and applications of solid dispersions and other systems, to enhance and regulate the delivery of poorly soluble drugs for oral therapy and nitric oxide for wound healing.
Research Challenge
For a drug to be effective, it must reach the target tissues at appropriate amounts. For an oral drug, this means overcoming several physiological challenges, including dissolving and surviving the harsh environment of the gut, crossing the gut lining to enter the bloodstream, and avoiding immediate destruction and removal from the circulation before reaching the target organ.
Many new drugs have low solubility and consequently poor bioavailability (the proportion of the administered drug capable of reaching the bloodstream unchanged), meaning that larger doses of the drugs are required to have an effect because so much of the drug does not get absorbed and reach its intended target. These poorly soluble new drugs have a crystalline structure, which makes them harder to dissolve and be absorbed. Therefore, more effective drug delivery systems are needed to achieve the desired therapeutic effect.
Ping Lee’s research focuses on developing new approaches, including the study of mechanisms and applications of solid dispersions and other systems, to enhance and regulate the delivery of poorly soluble drugs for oral therapy and nitric oxide for wound healing.
Research Challenge
For a drug to be effective, it must reach the target tissues at appropriate amounts. For an oral drug, this means overcoming several physiological challenges, including dissolving and surviving the harsh environment of the gut, crossing the gut lining to enter the bloodstream, and avoiding immediate destruction and removal from the circulation before reaching the target organ.
Many new drugs have low solubility and consequently poor bioavailability (the proportion of the administered drug capable of reaching the bloodstream unchanged), meaning that larger doses of the drugs are required to have an effect because so much of the drug does not get absorbed and reach its intended target. These poorly soluble new drugs have a crystalline structure, which makes them harder to dissolve and be absorbed. Therefore, more effective drug delivery systems are needed to achieve the desired therapeutic effect.
研究兴趣
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International journal of pharmaceutics (2023): 123122-123122
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