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Ron approached the complex entity of alcoholic liver disease in a focused, rational, and precise manner. Over the years, Ron’s body of work established the basic concepts that guide current research on alcoholic liver disease in laboratories throughout the world. He characterized hepatic alcohol metabolism and especially the adaptive swift increase in alcoholic metabilism that he liked to call “SIAM.” Ron’s seminal contributions established the role of lipopolysaccharides (LPS) to stimulate Kuppfer cell activation in the pathogenesis of alcoholic steatohepatitis.
Recently, using an intragastric ethanol feeding model in rats and mice, Ron defined the key genetic components in alcoholic steatohepatitis. By studies in knockout mice with viral gene delivery systems, he demonstrated critical roles of the tumor necrosis factor receptor-1 (ICAM-1), NADPH oxidase, CD14, and Toll-like receptor-4 in alcoholic liver injury.
The concept that emerged from Ron’s work was simple but unexpected: drinking alcohol promotes LPS translocation across the gut mucosa. The chronic exposure to LPS causes Kupffer cell activation and the release of cytokines, free radicals, and other inflammatory mediators that induce hepatocellular injury and may produce fibrosis as well. This concept of pathogenesis will surely guide alcohol research for many years to come.
Ron was a coauthor of more than 400 original research papers and he contributed many review articles and book chapters. He also attracted outstanding graduate students and postdoctoral fellows from all over the world. What’s more, he inspired them to strive for excellence. Alumni of his laboratory have pursued outstanding careers in clinical gastroenterology, gut research, and pharmacology. Ron presented superlative papers at meetings of the Association of Clinical Scientists (1996, 2001) and he was active in the American Gastroenterological Association, the American Association for the Study of Liver Diseases, and the Society of Toxicology. Recently, he became an associate editor of the journal, Gastroenterology.
In his curriculum vitae, Ron summarized his philosophy of education as follows: “I feel the best way to train graduate students is to be an appropriate role model. Accordingly, I see little difference between my research goals and my role as an educator. It is my aim to encourage graduate students to gather data sufficient for them to appreciate how exciting biomedical research can be, and then guide them through the publication process.”
Ron’s personal life was focused primarily around his research. His avocations included growing vegetables, travelling widely, and exploring new applications of his computer. He is survived by his parents, Mr. and Mrs. J. Glenn Thurman, who reside in Herrin IL.
Recently, using an intragastric ethanol feeding model in rats and mice, Ron defined the key genetic components in alcoholic steatohepatitis. By studies in knockout mice with viral gene delivery systems, he demonstrated critical roles of the tumor necrosis factor receptor-1 (ICAM-1), NADPH oxidase, CD14, and Toll-like receptor-4 in alcoholic liver injury.
The concept that emerged from Ron’s work was simple but unexpected: drinking alcohol promotes LPS translocation across the gut mucosa. The chronic exposure to LPS causes Kupffer cell activation and the release of cytokines, free radicals, and other inflammatory mediators that induce hepatocellular injury and may produce fibrosis as well. This concept of pathogenesis will surely guide alcohol research for many years to come.
Ron was a coauthor of more than 400 original research papers and he contributed many review articles and book chapters. He also attracted outstanding graduate students and postdoctoral fellows from all over the world. What’s more, he inspired them to strive for excellence. Alumni of his laboratory have pursued outstanding careers in clinical gastroenterology, gut research, and pharmacology. Ron presented superlative papers at meetings of the Association of Clinical Scientists (1996, 2001) and he was active in the American Gastroenterological Association, the American Association for the Study of Liver Diseases, and the Society of Toxicology. Recently, he became an associate editor of the journal, Gastroenterology.
In his curriculum vitae, Ron summarized his philosophy of education as follows: “I feel the best way to train graduate students is to be an appropriate role model. Accordingly, I see little difference between my research goals and my role as an educator. It is my aim to encourage graduate students to gather data sufficient for them to appreciate how exciting biomedical research can be, and then guide them through the publication process.”
Ron’s personal life was focused primarily around his research. His avocations included growing vegetables, travelling widely, and exploring new applications of his computer. He is survived by his parents, Mr. and Mrs. J. Glenn Thurman, who reside in Herrin IL.
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World Journal of Surgeryno. 4 (2014): 399-406
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