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Bio
We have established experimental sample processing pipelines for LC-MS analysis and developed several proteomics software pipelines for proteomics based on high throughput LC-MS. The unique feature of our software is that it can include many variable modifications (~40 have been tested) in a single search against the full protein database when searching state of art LC-MS data. We have also standardized the analysis of all main MS-based quantitative methods. This is a major breakthrough and we can demonstrate that current state of art MS is so sensitive that a large number of protein modifications can be found directly without tedious peptide enrichment for specific modifications. This technology will become even more significant as MS instruments get cheaper and more sensitive. We are currently working on commercializing this novel software tool for analysis of state of art LC-MS data. We will furthermore continue to use our sample preparation and software pipelines together with our collaborators in the COST action “PROTEOSTASIS” and pharmaceutical companies. We have for example previously had paid projects from GlaxoSmithKline, Novo Nordisk and Novartis.
Finally, we established biobanks for OSA and COPD which we are currently exploring by next generation sequencing and high throughput LC-MS for biomarker discovery. We aim in these projects to provide complete diagnostic tools including Bayesian software to be commercially explored.
Research Interests
Papers共 157 篇Author StatisticsCo-AuthorSimilar Experts
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Beatriz Serambeque, Catarina Mestre, Kristina Hundarova,Carlos Miguel Marto,Bárbara Oliveiros, Ana Rita Gomes,Ricardo Teixo,Ana Sofia Carvalho,Maria Filomena Botelho,Rune Matthiesen,Maria João Carvalho,Mafalda Laranjo
Biologyno. 8 (2024)
Nicolai B. Palstrom, Amanda J. Campbell, Caroline A. Lindegaard, Samir Cakar,Rune Matthiesen,Hans C. Beck
Beatriz Serambeque, Catarina Mestre, Gabriela Correia-Barros,Ricardo Teixo,Carlos Miguel Marto,Ana Cristina Goncalves,Francisco Caramelo,Isabel Silva,Artur Paiva,Hans C. Beck,Ana Sofia Carvalho,Maria Filomena Botelho,Maria Joao Carvalho,Rune Matthiesen,Mafalda Laranjo
Cancersno. 11 (2024): 2031-2031
Rui Miguel Marques Bernardino, Ana Sofia Carvalho,Luis Campos Pinheiro,Rashid Sayyid,Ricardo Leao,Hans Beck, Herminia Pereira,Rui Henrique,Neil Fleshner,Rune Matthiesen
JOURNAL OF UROLOGYno. 5 (2024): E43-E43
Pedro Baptista Pereira,Estefania Torrejon,Ines Ferreira,Ana Sofia Carvalho, Akiko Teshima,Ines Sousa-Lima,Hans Christian Beck,Bruno Costa-Silva,Rune Matthiesen,Maria Paula Macedo,Rita Machado de Oliveira
Neuza Domingues,Joana Gaifem,Rune Matthiesen,Diana P. Saraiva,Luis Bento,Maria I. L. Soares,Julio Sampaio,Christian Klose,Michal A. Surma,Manuel S. Almeida,Gustavo Rodrigues,Pedro Araujo Goncalves,Jorge Ferreira,Ryan Gouveia e Melo,Luis Mendes Pedro,Kai Simons,Andre R. A. Marques,Teresa M. V. D. Pinho Melo,M. Guadalupe Cabral,Antonio Jacinto,Ricardo Silvestre,Winchil Vaz,Otilia V. Vieira
M. Laranjo, C. Mestre,B. Serambeque,A. S. Carvalho, H. C. Beck,M. F. Botelho,M. J. Carvalho,R. Matthiesen
Annals of oncology (2023): S200-S200
DIABETOLOGIAno. SUPPL 1 (2023): S277-S277
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Author Statistics
#Papers: 160
#Citation: 4144
H-Index: 32
G-Index: 61
Sociability: 6
Diversity: 3
Activity: 75
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