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Dr. Regina Santella's research involves the use of biomarkers for the detection of human exposure to environmental and occupational carcinogens in molecular epidemiology studies to identify causative factors, susceptible populations, and preventive interventions. Her work has allowed the determination of exposure to carcinogens by the measurement of their binding to DNA with highly specific and sensitive immunoassays using monoclonal and polyclonal antibodies that her laboratory has developed. These studies have demonstrated higher levels of DNA damage in those with environmental or occupational exposures and in subjects with breast, lung, and liver cancer compared to controls. The role of genetic susceptibility in cancer risk is also being investigated with an emphasis on DNA repair capacity. Current studies seek to understand the role of environmental/lifestyle factors on epigenetic changes in DNA methylation and microRNA expression, how they impact cancer risk as well as whether epigenetic changes in can be used for early diagnosis of cancer.
Dr. Santella teaches "Biomarkers in Environmental Health Science".
Dr. Santella teaches "Biomarkers in Environmental Health Science".
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论文共 45 篇作者统计合作学者相似作者
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Coignard, Juliette,Lush, Michael,Beesley, Jonathan,O’Mara, Tracy A.,Dennis, Joe,Tyrer, Jonathan P., Barnes, Daniel R.,McGuffog, Lesley,Leslie, Goska,Bolla, Manjeet K., Adank, Muriel A.,Agata, Simona,
Nature Communicationsno. 1 (2021): 1-22
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