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My research group works on the physics of the Large Molecular Machines that perform most of the essential processes of life. We currently focus on Rotary Molecular Motors, in particular the Bacterial Flagellar Motor and F1FO ATP-synthase. The aim is to try and understand how these living machines work.
We use a range of techniques. Molecular motors are tens of nanometres in size, and we measure their motion using novel forms of light microscopy to follow visible "handles" such as sub-micron gold or polystyrene spheres and rods, and single fluorescent molecules. We measure the position of the handles with nanometre and sub-millisecond resolution using fluorescence microscopy, laser dark-field microscopy and laser interferometry. Optical tweezers (3-D laser traps) and magnetic tweezers are used to push single motors around. We also use single-molecule fluorescence microscopy to detect separate components of the motors and assess how they interact with each other.
We use a range of techniques. Molecular motors are tens of nanometres in size, and we measure their motion using novel forms of light microscopy to follow visible "handles" such as sub-micron gold or polystyrene spheres and rods, and single fluorescent molecules. We measure the position of the handles with nanometre and sub-millisecond resolution using fluorescence microscopy, laser dark-field microscopy and laser interferometry. Optical tweezers (3-D laser traps) and magnetic tweezers are used to push single motors around. We also use single-molecule fluorescence microscopy to detect separate components of the motors and assess how they interact with each other.
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Haidai Hu, Thomas C.D. Hughes,Philipp F. Popp, Aritz Roa-Eguiara, Freddie J.O. Martin, Nicole R. Rutbeek,Ivo Alexander Hendriks,Leighton J. Payne,Yumeng Yan, Victor Klein de Sousa,Yong Wang,Michael Lund Nielsen,
biorxiv(2023)
ACS materials Auno. 2 (2022): 176-189
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