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职业迁徙
个人简介
My Research
KEYWORDS
tumor metabolism, iron-sulfur clusters, breast cancer, mitochondrial function, serine biosynthesis, cancer, metabolism, mTOR
SUMMARY
Our laboratory focuses on identifying metabolic pathways that are altered in the transformed state, understanding how those pathways support transformation, and investigating the environmental, genetic and epigenetic contexts in which such pathways act. Of particular interest are investigating serine and glycine metabolism and iron-sulfur cluster metabolism as well as exploring the potential ways by which mutations in the mitochondrial genome support cellular transformation. We attack these problems with a combination of approaches that endeavor to push the boundaries of genetic screening, mammalian cell culture, and metabolomic methods.
KEYWORDS
tumor metabolism, iron-sulfur clusters, breast cancer, mitochondrial function, serine biosynthesis, cancer, metabolism, mTOR
SUMMARY
Our laboratory focuses on identifying metabolic pathways that are altered in the transformed state, understanding how those pathways support transformation, and investigating the environmental, genetic and epigenetic contexts in which such pathways act. Of particular interest are investigating serine and glycine metabolism and iron-sulfur cluster metabolism as well as exploring the potential ways by which mutations in the mitochondrial genome support cellular transformation. We attack these problems with a combination of approaches that endeavor to push the boundaries of genetic screening, mammalian cell culture, and metabolomic methods.
研究兴趣
论文共 73 篇作者统计合作学者相似作者
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Cancer researchno. 6 (2024): 935-935
Katharine Lu Yang, Briana J Mullins,Alannah Lejeune,Ellie Ivanova,Jong Shin, Sofia Bajwa,Richard Possemato,Ken Cadwell,Jose U Scher,Sergei B Koralov
Arthritis & rheumatology (Hoboken, N.J.)no. 4 (2024): 647-659
Brian C. Grabiner,Valentina Nardi,Kıvanç Birsoy,Richard Possemato,Kuang Shen, Sumi Sinha, Alexander Jordan,Andrew H. Beck,David M. Sabatini
crossref(2023)
Yuyang Liu, Shanshan Liu, Anju Tomar,Frederick S. Yen,Gokhan Unlu, Nathalie Ropek,Ross A. Weber,Ying Wang,Artem Khan, Mark Gad,Junhui Peng,Erdem Terzi,
crossref(2023)
Jong Shin, Hannan Mir, Maaz A. Khurram,Kenji M. Fujihara,Brian D. Dynlacht,Timothy J. Cardozo,Richard Possemato
Brian C. Grabiner,Valentina Nardi,Kıvanç Birsoy,Richard Possemato,Kuang Shen, Sumi Sinha, Alexander Jordan,Andrew H. Beck,David M. Sabatini
crossref(2023)
crossref(2023)
Tobias Schraink, Lili Blumenberg,Grant Hussey, Sabrina George, Brecca Miller, Nithu Mathew, Tania J González-Robles,Vladislav Sviderskiy, Thales Papagiannakopoulos,Richard Possemato, David Fenyö,Kelly V Ruggles
Molecular & cellular proteomics : MCPno. 8 (2023): 100596-100596
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