基本信息
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职业迁徙
个人简介
Research interests
Pharmacological investigations in cancer and other diseases conducted in vitro and in vivo, included a variety of anticancer agents, e.g. novel anthracyclines, the biochemical modulation of 5-fluorouracil focusing on the stereospecific pharmacokinetics of folates in patients with colorectal cancer and intratumoural pharmacokinetics of drugs using the microdialysis technique in close collaboration with the Department of Clinical Pharmacology. Always actively participating in clinical trials, molecular pharmacology and drug resistance mechanisms became a central part of research with a focus on a variety of cellular cancer models. For the time being, microRNA are investigated as regulatory molecules during the development of drug resistance and endothelial intravasation during metastasis formation, where exosomal microRNA function as “malignant” messengers between cells. Our contribution to the era of personalised medicine was the EXACT trail, where we were able to demonstrate the feasibility of this concept, which benefited patients without established treatment option in a huge team effort.
Pharmacological investigations in cancer and other diseases conducted in vitro and in vivo, included a variety of anticancer agents, e.g. novel anthracyclines, the biochemical modulation of 5-fluorouracil focusing on the stereospecific pharmacokinetics of folates in patients with colorectal cancer and intratumoural pharmacokinetics of drugs using the microdialysis technique in close collaboration with the Department of Clinical Pharmacology. Always actively participating in clinical trials, molecular pharmacology and drug resistance mechanisms became a central part of research with a focus on a variety of cellular cancer models. For the time being, microRNA are investigated as regulatory molecules during the development of drug resistance and endothelial intravasation during metastasis formation, where exosomal microRNA function as “malignant” messengers between cells. Our contribution to the era of personalised medicine was the EXACT trail, where we were able to demonstrate the feasibility of this concept, which benefited patients without established treatment option in a huge team effort.
研究兴趣
论文共 317 篇作者统计合作学者相似作者
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JOURNAL OF PERSONALIZED MEDICINEno. 8 (2023)
FRONTIERS IN CARDIOVASCULAR MEDICINE (2023): 1030842-1030842
crossref(2023)
crossref(2023)
ESC heart failureno. 6 (2023): 3559-3572
The Lancetno. 10394 (2023): 2138-2147
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