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个人简介
Circadian rhythm, translational control, neuropsychiatric disorders Circadian (~24 h) rhythmicity is an evolutionarily conserved property that regulates fundamental biological processes. Rhythmic gene expression is found in a variety of cells and tissues. In mammals, the master pacemaker is located in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN relays photic information from the retina to the brain to synchronize endogenous rhythms to ambient light/dark cycles. Disruption of the circadian rhythm and body clock function is associated with many human diseases.
We are interested in mRNA translational control mechanisms that regulate the functions of the circadian clock and how dysregulated translational control is involved in circadian dysfunction in neurological and psychiatric diseases. We are particularly interested in the role of the mammalian target of rapamycin (mTOR) signaling and integrated stress response as the coupling mechanisms between cell metabolism and the circadian clock.
We are interested in mRNA translational control mechanisms that regulate the functions of the circadian clock and how dysregulated translational control is involved in circadian dysfunction in neurological and psychiatric diseases. We are particularly interested in the role of the mammalian target of rapamycin (mTOR) signaling and integrated stress response as the coupling mechanisms between cell metabolism and the circadian clock.
研究兴趣
论文共 33 篇作者统计合作学者相似作者
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Physiologyno. S1 (2024)
METABOLITESno. 2 (2024): 126
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2024): 105523-105523
CLOCKS & SLEEPno. 4 (2023): 639-650
FRONTIERS IN NEUROSCIENCE (2021): 642745-642745
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