基本信息
浏览量:9
职业迁徙
个人简介
Research Interests
Angiogenesis, antiangiogenic proteins/peptides, cancer, inflammation, COPD, and drug discovery:
Angiogenesis (new blood vessel formation) is essential for embryonic development and adult physiological functions such as wound healing, reproduction and tissue homeostasis. Abnormal angiogenesis is involved in more than 70 human diseases including cancer. To suppress cancer through inhibiting tumor angiogenesis has been actively pursued as an anticancer therapeutic approach.
In recent years, we have focused on identifying and investigating novel endogenous anti-angiogenesis proteins that contain the thrombospondin type 1 repeat domain (TSR). These endogenous proteins are not only valuable for anticancer drug development, but also important for understanding tissue homeostasis and organ function. So far, we have identified 3 novel endogenous antiangiogenic proteins: Isthmin 1 (ISM1), ADAMTS5 and ADAMTS4. We use CRISPR/Cas9 gene editing approach to generate knockout mice for functional investigations. We also study the mechanisms of action of these proteins using cultured primary human endothelial cells and various molecular and cell biology approaches.
Notably, we discovered a previously unrecognized protein trafficking pathway from late endosome to mitochondria which allows extracellular antiangiogenic proteins to reach mitochondria via endocytosis and execute apoptosis. We believe this is a fundamental protein trafficking pathway that is likely to exist in many cell types. We are currently investigating what are the key players in this protein trafficking pathway and how late endosome interact and fuse with mitochondria.
We have also extended our research into inflammation suppression and resolution. By serendipity, we discovered a novel protein suppressor that can quench cigarette-smoke induced Chronic Obstructive Pulmonary Disease (COPD) in mice. We are currently investigating the mechanism of action of this novel inflammation suppressor in COPD as well as its roles in other inflammatory lung diseases such as acute lung injury (ALI) and idiopathic pulmonary fibrosis (IPF).
Angiogenesis, antiangiogenic proteins/peptides, cancer, inflammation, COPD, and drug discovery:
Angiogenesis (new blood vessel formation) is essential for embryonic development and adult physiological functions such as wound healing, reproduction and tissue homeostasis. Abnormal angiogenesis is involved in more than 70 human diseases including cancer. To suppress cancer through inhibiting tumor angiogenesis has been actively pursued as an anticancer therapeutic approach.
In recent years, we have focused on identifying and investigating novel endogenous anti-angiogenesis proteins that contain the thrombospondin type 1 repeat domain (TSR). These endogenous proteins are not only valuable for anticancer drug development, but also important for understanding tissue homeostasis and organ function. So far, we have identified 3 novel endogenous antiangiogenic proteins: Isthmin 1 (ISM1), ADAMTS5 and ADAMTS4. We use CRISPR/Cas9 gene editing approach to generate knockout mice for functional investigations. We also study the mechanisms of action of these proteins using cultured primary human endothelial cells and various molecular and cell biology approaches.
Notably, we discovered a previously unrecognized protein trafficking pathway from late endosome to mitochondria which allows extracellular antiangiogenic proteins to reach mitochondria via endocytosis and execute apoptosis. We believe this is a fundamental protein trafficking pathway that is likely to exist in many cell types. We are currently investigating what are the key players in this protein trafficking pathway and how late endosome interact and fuse with mitochondria.
We have also extended our research into inflammation suppression and resolution. By serendipity, we discovered a novel protein suppressor that can quench cigarette-smoke induced Chronic Obstructive Pulmonary Disease (COPD) in mice. We are currently investigating the mechanism of action of this novel inflammation suppressor in COPD as well as its roles in other inflammatory lung diseases such as acute lung injury (ALI) and idiopathic pulmonary fibrosis (IPF).
研究兴趣
论文共 115 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Jong Huat Tee,Udhaya Vijayakumar,Mahalakshmi Shanmugasundaram, Terence Y. W. Lam,Wupeng Liao, Yuansheng Yang,W. S. Fred Wong,Ruowen Ge
RESPIRATORY RESEARCHno. 1 (2023): 1-20
Ellenmae W X Leong,Ruowen Ge
Annals of Translational Medicineno. 20 (2022): 0-0
Terence Y W Lam,Ngan Nguyen,Hong Yong Peh,Mahalakshmi Shanmugasundaram,Ritu Chandna,Jong Huat Tee,Chee Bing Ong,Md Zakir Hossain,Shruthi Venugopal, Tianyi Zhang,Simin Xu,Tao Qiu,
Molecular Biomedicine (Online)no. 1 (2020): 11
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn