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Spermatogenesis is a complex process requiring extensive changes in the chromatin and epigenetic landscape for proper specification and differentiation. Aberrations in this process can lead to infertility, a major health problem worldwide, affecting 1 in every 6 couples. Approximately 50% of the infertility cases lack a clear etiology. Therefore, a greater understanding of the molecular mechanism / pathways required for proper germ cell development is required to develop effective treatments or alternative therapies to restore spermatogenesis.
Spermatogenesis is a complex process requiring extensive changes in the chromatin and epigenetic landscape for proper specification and differentiation. Aberrations in this process can lead to infertility, a major health problem worldwide, affecting 1 in every 6 couples. Approximately 50% of the infertility cases lack a clear etiology. Therefore, a greater understanding of the molecular mechanism / pathways required for proper germ cell development is required to develop effective treatments or alternative therapies to restore spermatogenesis.
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Andrea S. K. Jones, D. Ford Hannum,Jordan H. Machlin, Ansen Tan,Qianyi Ma,Nicole D. Ulrich,Yu-chi Shen, Maria Ciarelli,Vasantha Padmanabhan,Erica E. Marsh,Sue Hammoud,Jun Z. Li,
SCIENCE ADVANCESno. 14 (2024): eadm7506-eadm7506
bioRxiv : the preprint server for biology (2024)
Nature structural & molecular biologyno. 8 (2023): 1077-1091
Communications biologyno. 1 (2023): 264-15
Developmental cellno. 7 (2022): 914-929.e7
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