基本信息
浏览量:42
职业迁徙
个人简介
I graduated from the University of Milan (Italy) in Medical Biotechnology in 2003 and gained a Ph.D. in Translational and Molecular Medicine in 2008 at the University of Milan-Bicocca.
For my post-doctoral training, I was awarded a Marie Curie Intra-European Fellowship in 2010 and worked as a Research Associate in the Department of Clinical Neurosciences of Cambridge University (UK). In February 2011, I was elected as a Research Fellow of Hughes Hall, one of the 31 colleges in Cambridge. In 2013, I started a collaboration with the University of Texas Southwestern Medical Center in Dallas (USA) and visited the institution between 2014-2016 as Visiting Senior Scientist.
In 2016, I was recruited to UT Southwestern Medical Center as a Faculty Member of Internal Medicine and in 2018 I was promoted to Research Assistant Professor at the same institution. In 2019, I joined the University of New Mexico Health Sciences Center as a Tenure-Track Assistant Professor in the Department of Cell Biology & Physiology and a Full Member of the UNM Comprehensive Cancer Center.
My research over the past nineteen years has had a major focus on the relationship between the genotype and the phenotype of the so-called 'cancer stem-like cells' in the most aggressive brain tumor in adults, i.e. glioblastoma (GBM). During my Ph.D. at the University of Milan-Bicocca (Italy), my work focused on key regulatory stem cell mechanisms of self-renewal and differentiation that are hijacked by tumor cells. Specifically, we identified a new therapeutic approach based on the induction of differentiation in GBM cells and determined the in vivo efficacy of a pro-differentiation therapy using patient-derived xenograft models (Piccirillo S.G. et al., Nature 2006). This work led to a patent application and to the development of a pro-differentiating therapeutic agent that has completed Phase I clinical trial in 2020.
My research also contributed to reveal that phenotypically and genetically distinct cancer stem-like cells coexist in the same GBM (Piccirillo S.G. et al., Oncogene 2009) and in areas of residual disease such as the tumor margin (Piccirillo S.G. et al., Br J Cancer 2012) and the sub-ventricular zone of the lateral ventricles (Piccirillo S.G. et al., Cancer Research 2015). Cancer stem-like cells from these areas contribute to patient-specific evolutionary trajectories of GBM growth and seed the recurrent tumor that is inevitable in GBM patients (Spiteri I., et al., Annals of Oncology 2019).
The research focus of my laboratory is the analysis of the functional consequences of the extensive genetic and phenotypic heterogeneity of GBM. Specifically, we are interested in investigating the impact of intra-tumor heterogeneity on therapeutic resistance and tumor growth after treatment. We integrate genomic measurements with the phenotypic analysis of cancer stem-like cells and use this information to gain mechanistic insights into the development of therapeutic resistance.
研究兴趣
论文共 78 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Y Licón-Muñoz, V Avalos, S Subramanian, B Granger,F Martinez,S Varela, D Moore,E Perkins, M Kogan,S Berto, M O Chohan,C A Bowers,S G M Piccirillo
bioRxiv : the preprint server for biology (2024)
Chad Smith,Kiel M. Telesford,Sara G. M. Piccirillo,Yamhilette Licon-Munoz, Wei Zhang, Key M. Tse,Jacqueline R. Rivas,Chaitanya Joshi, Dilan S. Shah, Angela X. Wu, Ritu Trivedi,Scott Christley, Yu Qian,Lindsay G. Cowell,Richard H. Scheuermann,Ann M. Stowe, Linda Nguyen,Benjamin M. Greenberg,Nancy L. Monson
Journal of Neuroinflammationno. 1 (2024): 1-16
Leopoldo A Garcia-Montano,Yamhilette Licon-Munoz,Frank J Martinez, Yasine R Keddari, Michael K Ziemke,Muhammad O Chohan,Sara G M Piccirillo
Molecular Cancer Research (2023): 755-767
Bioinformaticsno. 9 (2023)
crossref(2023)
Cancer researchno. 7_Supplement (2023): 5802-5802
Leopoldo A. Garcia-Montano, Yamhilette Licon Munoz,Frank Martinez,Kandee Gallegos,Huining Kang,Sara G. Piccirillo
CANCER RESEARCHno. 7 (2023)
Cell Reportsno. 8 (2020): 2489-2500.e5
加载更多
作者统计
#Papers: 79
#Citation: 6399
H-Index: 25
G-Index: 43
Sociability: 6
Diversity: 2
Activity: 2
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn