基本信息
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职业迁徙
个人简介
The Scadden lab emphasizes using multidisciplinary approaches to define novel therapies for blood diseases. His lab has been recognized for pioneering work in the bone marrow microenvironment, defining that alteration of stromal components of the stem cell niche can induce hematologic malignancies and discovering novel methods to improve hematopoietic stem cell transplantation. The lab has demonstrated previously unrecognized constraints on blood stem cell plasticity and a means by which altering leukemic cell metabolism can overcome differentiation blockade leading to cancer cell death. The emphasis of the lab is exploring the fundamental biology of blood cell production while prioritizing areas where insights may lead to therapeutics.
研究兴趣
论文共 90 篇作者统计合作学者相似作者
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Laure Maneix,Polina Iakova, Charles G Lee,Shannon E Moree, Xuan Lu,Gandhar K Datar, Cedric T Hill,Eric Spooner,Jordon C K King,David B Sykes, Borja Saez,Bruno Di Stefano,
Nature cell biologypp.1-11, (2024)
Shenglin Mei,Adele M. Alchahin,Ioanna Tsea,Youmna Kfoury,Taghreed Hirz, Nathan Elias Jeffries,Ting Zhao, Yanxin Xu, Hanyu Zhang,Hirak Sarkar,Shulin Wu,Alexander O. Subtelny,
Journal of visualized experiments : JoVE (2024)
Gracia Bonilla, Alexander Morris, Sharmistha Kundu, Anthony Ducasse, Nathan E Jeffries,Kashish Chetal, Emma E Yvanovich, Rana Barghout,David Scadden,Michael K Mansour, Robert E Kingston,David B Sykes,
bioRxiv : the preprint server for biology (2024)
Giulia Schiroli,Vinay K Kartha,Fabiana M Duarte, Trine Ahn Kristiansen, Christina Mayerhofer,Rojesh Shrestha,Andrew Earl,Yan Hu,Tristan Tay,Catherine Rhee,Jason Buenrostro,David T Scadden
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Blood advancesno. 21 (2023): 6608-6623
Bloodno. 7 (2023): 658-674
Mei Massengale, Justin L Massengale, Catherine R Benson, Ninib Barywano,Toshihiko Oki, Matthew L Steinhauser, Alissa Wang,Deepak Balani,Luke S Oh,Mark A Randolph,Thomas J Gill,Henry M Kronenberg,
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Cancer Researchno. 7_Supplement (2023): 2456-2456
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