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Research
The overall research theme of our group is to understand molecular identity and functions of fat-derived stem cells and to make use of them for treating metabolic disorders.
1. Molecular identification of adipose-derived stem cells
A research interest of our group is to delineate the molecular identity of adipose-derived stem cells (ASC) and metabolic pathways initiating adipocyte differentiation by using bioimaging and other analytic approaches. We are investigating several mouse and human models of obesity, lipodystrophy and other metabolic disorders. Active studies are also ongoing to study the biological difference between adipose stem cells from visceral and subcutaneous fat depots. For example, through high throughput image screening, we recently identified specific cell surface markers, CD10 for human subcutaneous ASC and CD200 for visceral ASC. We are also using other factors as a biological tool to track early adipose development; e.g. PPARgamma, which a ligand-regulated transcription factor and a master regulator of adipogenesis.
2. Therapeutic application of adipose-derived stem cells
Fat tissue is an abundant source of proliferating, multipotent stem cells, which offers high potentials for regenerative medicine. Our previous work demonstrated that the adipose-derived stem cells (ASC) both from human and mice are capable of reprogramming into induced pluripotent stem cells (iPSC) with high efficiencies and in the absence of feeder cells. It is now possible to use this ASC-iPSC system to engineer the cells into clinically useful cell types (e.g. cardiomyocytes, pancreatic beta cells, hepatocytes, brown adipocytes) for regenerative therapeutics and study development of metabolic pathways. By collaborating with other groups including imaging specialists and clinician scientists, we develop a suitable platform for cellular modeling, transplantation and tracking where human fat biopsies are converted into relevant cell types, enabling us to explore molecular mechanisms and treatment options for metabolic diseases. This ASC-iPSC system will be valuable for personalized drug screening/testing, human disease modeling, and ultimately, cell therapies.
The overall research theme of our group is to understand molecular identity and functions of fat-derived stem cells and to make use of them for treating metabolic disorders.
1. Molecular identification of adipose-derived stem cells
A research interest of our group is to delineate the molecular identity of adipose-derived stem cells (ASC) and metabolic pathways initiating adipocyte differentiation by using bioimaging and other analytic approaches. We are investigating several mouse and human models of obesity, lipodystrophy and other metabolic disorders. Active studies are also ongoing to study the biological difference between adipose stem cells from visceral and subcutaneous fat depots. For example, through high throughput image screening, we recently identified specific cell surface markers, CD10 for human subcutaneous ASC and CD200 for visceral ASC. We are also using other factors as a biological tool to track early adipose development; e.g. PPARgamma, which a ligand-regulated transcription factor and a master regulator of adipogenesis.
2. Therapeutic application of adipose-derived stem cells
Fat tissue is an abundant source of proliferating, multipotent stem cells, which offers high potentials for regenerative medicine. Our previous work demonstrated that the adipose-derived stem cells (ASC) both from human and mice are capable of reprogramming into induced pluripotent stem cells (iPSC) with high efficiencies and in the absence of feeder cells. It is now possible to use this ASC-iPSC system to engineer the cells into clinically useful cell types (e.g. cardiomyocytes, pancreatic beta cells, hepatocytes, brown adipocytes) for regenerative therapeutics and study development of metabolic pathways. By collaborating with other groups including imaging specialists and clinician scientists, we develop a suitable platform for cellular modeling, transplantation and tracking where human fat biopsies are converted into relevant cell types, enabling us to explore molecular mechanisms and treatment options for metabolic diseases. This ASC-iPSC system will be valuable for personalized drug screening/testing, human disease modeling, and ultimately, cell therapies.
研究兴趣
论文共 66 篇作者统计合作学者相似作者
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Chan Du, Kelene K. L. Choy, Lamony J. M. Chew,Maria N. Antipina, Valerie J. Y. Chng, Sebastian H. A. Su,Benjamin C. U. Tai,Raffael Osen,Shigeki Sugii,Andrew C. A. Wan
JOURNAL OF FOOD ENGINEERING (2023)
TRENDS IN BIOTECHNOLOGYno. 5 (2023): 686-700
Comprehensive Reviews in Food Science and Food Safetyno. 5 (2022): 4146-4163
Advances in Magnetic Resonance Technology and ApplicationsQuantitative Magnetic Resonance Imagingpp.667-679, (2020)
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作者统计
#Papers: 66
#Citation: 3019
H-Index: 26
G-Index: 54
Sociability: 5
Diversity: 3
Activity: 19
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