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She has been recognized by various national and international societies with the Wybran and the Distinguished Service Awards. She was also awarded the Kansas City scientist award in 2011 and the prestigious UNMC Scientist laureate award in 2015. Aligning closely with her passion for mentoring enabled her to take an active leading role in the Women’s Mentoring Program at UNMC.
She has also been the recipient of the Women in Neuroscience award in 2016 at the International Society of Neurovirology. She has successfully graduated from the Executive Leadership for Academic Medicine Program that fosters the growth and
career trajectories of women leaders nationally.
Prof. Buch has published over 190 SCI papers with more than 10,000 citations and an
H-index of 44 and is a coordinator and a principal leader of several national and
international research and collaborative projects.
Research Interests:
The Chemokine Connection: CXCL10 or interferon γ-inducible peptide has been detected in the CSF of individuals with HIV-1 infection and is closely associated with the progression of HIV-1 related CNS infection and neuropsychiatric impairment. Using the macaque model of HIV neuropathogenesis, we have identified the role of this chemokine as a potent neurotoxin that is linked to virus-associated encephalitis. Specifically, we have demonstrated the signaling pathways by which viral proteins cause regulated induction of this chemokine, thereby resulting in apoptotic cell death. Additionally, papers from our laboratory suggest that in astrocytes, the interplay of viral proteins with the inflammatory mediators (IFN-γ/TNF-α) can lead to synergistic induction of this neurotoxin, via the oxidative stress pathway.
Endogenous Neuroprotective Pathways: CNS homeostasis is a fine balance of neuroprotective and neurotoxic pathways. However, this can be a double-edged sword, as a well-intentioned protective response, if extended for a long time, can go awry. We have been interested in exploring endogenous cellular pathways that can augment neuronal survival. In our recent findings we report unconventional role for the HAD-associated chemokine, MCP-1 - that of neuroprotection against virus toxicity. Similarly, we have also reported the paradoxical role of platelet-derived growth factor as a neuroprotective factor against HIV toxicity. These are very intriguing findings as they lend credence to the existence of selective "anatomical niches" in the CNS. Our ultimate goal is to examine the roles of these host mediators as therapeutic agents that can mitigate CNS inflammation and impaired synaptic transmission in vivo.
Drugs of Abuse and HIV Co-operativity: Injection drug abuse is a major cause of the spread of HIV/AIDS. Heroin, morphine and other opioids not only promote HIV infection and the progression of AIDS, but also appear to intrinsically exacerbate the frequency and severity of HIV encephalitis (HIVE) in the CNS. We are actively pursuing how cocaine synergizes with HIV/HIV proteins to exacerbate disease pathogenesis. Our findings imply that that cocaine can act at multiple steps within the CNS to promote neuronal toxicity, specifically impacting the blood brain barrier breach and enhancing virus replication in macrophages. Another highly relevant area of research in our lab is aimed at examining the effect of morphine on progression of HIVE in SIV-infected macaques, which are an excellent analog of HIV encephalopathy.
HIV, aging and NeuroAIDS: The now chronic nature of HIV has led to a major advancement in AIDS care. While HIV infected individuals are living longer, damaging effects of HIV persist in the brain and may interact with other neurodegenerative disorders. Dr. Buch, along with dR. Howard Fox, leads the Chronic HIV infection and Aging in NeuroAIDS Center (CHAIN). The Center is supported by NIH, NIMH P30 MH062261. The goal of the CHAIN Center is to provide the necessary leadership and backbone of support to continue the outstanding research on HIV/AIDS, aging and the central nervous system ongoing at the University of Nebraska Medical Center and throughout the nation. Experts in a number of fields direct the Cell-Tissue-Animal, Imaging, Omics, and Therapeutics cores, along with the Administrative and Developmental cores. Visit the CHAIN Center web site for more information.
She has also been the recipient of the Women in Neuroscience award in 2016 at the International Society of Neurovirology. She has successfully graduated from the Executive Leadership for Academic Medicine Program that fosters the growth and
career trajectories of women leaders nationally.
Prof. Buch has published over 190 SCI papers with more than 10,000 citations and an
H-index of 44 and is a coordinator and a principal leader of several national and
international research and collaborative projects.
Research Interests:
The Chemokine Connection: CXCL10 or interferon γ-inducible peptide has been detected in the CSF of individuals with HIV-1 infection and is closely associated with the progression of HIV-1 related CNS infection and neuropsychiatric impairment. Using the macaque model of HIV neuropathogenesis, we have identified the role of this chemokine as a potent neurotoxin that is linked to virus-associated encephalitis. Specifically, we have demonstrated the signaling pathways by which viral proteins cause regulated induction of this chemokine, thereby resulting in apoptotic cell death. Additionally, papers from our laboratory suggest that in astrocytes, the interplay of viral proteins with the inflammatory mediators (IFN-γ/TNF-α) can lead to synergistic induction of this neurotoxin, via the oxidative stress pathway.
Endogenous Neuroprotective Pathways: CNS homeostasis is a fine balance of neuroprotective and neurotoxic pathways. However, this can be a double-edged sword, as a well-intentioned protective response, if extended for a long time, can go awry. We have been interested in exploring endogenous cellular pathways that can augment neuronal survival. In our recent findings we report unconventional role for the HAD-associated chemokine, MCP-1 - that of neuroprotection against virus toxicity. Similarly, we have also reported the paradoxical role of platelet-derived growth factor as a neuroprotective factor against HIV toxicity. These are very intriguing findings as they lend credence to the existence of selective "anatomical niches" in the CNS. Our ultimate goal is to examine the roles of these host mediators as therapeutic agents that can mitigate CNS inflammation and impaired synaptic transmission in vivo.
Drugs of Abuse and HIV Co-operativity: Injection drug abuse is a major cause of the spread of HIV/AIDS. Heroin, morphine and other opioids not only promote HIV infection and the progression of AIDS, but also appear to intrinsically exacerbate the frequency and severity of HIV encephalitis (HIVE) in the CNS. We are actively pursuing how cocaine synergizes with HIV/HIV proteins to exacerbate disease pathogenesis. Our findings imply that that cocaine can act at multiple steps within the CNS to promote neuronal toxicity, specifically impacting the blood brain barrier breach and enhancing virus replication in macrophages. Another highly relevant area of research in our lab is aimed at examining the effect of morphine on progression of HIVE in SIV-infected macaques, which are an excellent analog of HIV encephalopathy.
HIV, aging and NeuroAIDS: The now chronic nature of HIV has led to a major advancement in AIDS care. While HIV infected individuals are living longer, damaging effects of HIV persist in the brain and may interact with other neurodegenerative disorders. Dr. Buch, along with dR. Howard Fox, leads the Chronic HIV infection and Aging in NeuroAIDS Center (CHAIN). The Center is supported by NIH, NIMH P30 MH062261. The goal of the CHAIN Center is to provide the necessary leadership and backbone of support to continue the outstanding research on HIV/AIDS, aging and the central nervous system ongoing at the University of Nebraska Medical Center and throughout the nation. Experts in a number of fields direct the Cell-Tissue-Animal, Imaging, Omics, and Therapeutics cores, along with the Administrative and Developmental cores. Visit the CHAIN Center web site for more information.
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BRAINno. 2 (2024): 335-336
JOURNAL OF NEUROVIROLOGY (2023): S10-S10
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AMERICAN JOURNAL OF PATHOLOGYno. 4 (2023): 380-391
Journal of neurovirologyno. 4 (2023): 377-388
JOURNAL OF NEUROVIROLOGY (2023): S8-S8
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JOURNAL OF NEUROVIROLOGY (2023): S24-S25
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JOURNAL OF NEUROVIROLOGY (2023): S4-S4
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Advances in Drug and Alcohol Research (2023): 11092-11092
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