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The skin serves as an important barrier that keeps moisture in the body and prevents the incursion of harmful exogenous agents, such as irritants and allergens, and resists the invasion of pathogens. A growing body of evidence suggests a primary role for the ‘skin barrier’ in the pathogenesis of a broad range of inflammatory skin disorders, including contact dermatitis, ichthyosis, psoriasis, rosacea and atopic dermatitis (AD). Repeated barrier disruption for instance induces epidermal hyperplasia and inflammation. Current medicine is based on the reactive treatment of these downstream consequences of skin barrier dysfunction, and includes the use of both anti-inflammatory and anti-proliferative compounds. My research focuses on increasing our understanding of the skin barrier defect and developing treatments to correct it under the following core themes:
Gene-environment interactions in the development of atopic dermatitis
Development of treatments for atopic dermatitis
The improvement of neonatal skincare
Interaction of topical pharmaceutical and cosmetic agents with the skin barrier
A greater understanding of the underlying skin barrier defect promises to firstly identify susceptible individuals early on, and secondly to deliver novel therapeutic options for targeted skin barrier repair with the potential to prevent the development of clinical disease.
研究兴趣
论文共 86 篇作者统计合作学者相似作者
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Irina Bronova,Evgeny Berdyshev,Elena Goleva,Simon Danby,Anna Sofia Bronoff,Brittany Richers,Shannon Garcia,Marco Ramirez Gama,Patricia Taylor, Joseph Zahn, Inoncent Agueusop, Shantanu Bafna,
Journal of Allergy and Clinical Immunologyno. 2 (2024): AB5
Dermatology and Therapyno. 2 (2024): 391-408
Samuel F. Williams, Helen Wan,John Chittock,Kirsty Brown, Andrew Wigley,Michael J. Cork,Simon G. Danby
CLINICAL AND EXPERIMENTAL DERMATOLOGYno. 5 (2024): 466-477
FRONTIERS IN VIROLOGY (2023)
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BIOMEDICAL OPTICS EXPRESSno. 8 (2023): 4126-4136
Inmaculada Barragan Vazquez,Simon Danby, Vicente Marco Garcia Gonzalez, Rosa Lopez Almagro, Maria Isabel Crespo Crespo,Helen Colley,Craig Murdoch
TISSUE ENGINEERING PART Ano. 11-12 (2023): 492-492
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Amy L. Harding,Helen E. Colley, Inmaculada Barragan Vazquez,Simon Danby,Md Zobaer Hasan,Hirofumi Nakanishi,Tetsuo Furuno,Craig Murdoch
EXPERIMENTAL DERMATOLOGYno. 2 (2023): 220-225
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICEno. 5 (2023): 1335-1346
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