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个人简介
The group led by Søren Moestrup investigates the role of macrophages receptors in inflammation such as the receptor CD163 that removes hemoglobin and haptoglobin from the circulation.
One focus is on characterizing the ligand binding of CD163, including identification of novel ligands. Another focus is on the development of techniques for specifically targeting small molecule drugs to macrophages, using monoclonal antibodies to make novel antibody-drug conjugates or targeted liposomes, both binding CD163. The macrophage plays a pivotal role in inflammation as the main producer of a range of pro-inflammatory cytokines, such as TNF and IL-1. By targeting glucocorticoids to the macrophages we can specifically inhibit the production of these pro-inflammatory cytokines, and we have shown that the efficacy of glucocorticoids is increased by a factor 50 through this specific targeting. The drug has been tested in inflammatory models in pigs, mice and rats. We are currently establishing other inflammatory models in order to characterize the role of the macrophage in other diseases and validate the specific targeting approach. In addition, a special subtype of the macrophage, the tumor associated macrophage, promotes the growth of tumors, and we are also working on targeting these cells. The work in the laboratory ranges from early receptor identification, recombinant expression and purification of proteins, over characterization of receptor binding, to in vitro and in vivo testing of drug candidates.
研究兴趣
论文共 354 篇作者统计合作学者相似作者
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Gastro Hep advancesno. 5 (2023): 711-720
Cancersno. 6 (2023): 1830-1830
Sara A. Ferreira,Conghui Li,Ida H. Klæstrup, Zagorka Vitic, Rikke K. Rasmussen, Asger Kirkegaard, Gitte U. Toft,Cristine Betzer,Pia Svendsen,Poul H. Jensen,Yonglun Luo,Anders Etzerodt,Søren K. Moestrup,Marina Romero-Ramos
npj Parkinson's Diseaseno. 1 (2023): 1-21
Roeland Kindt,Sammy Carsan,Lars Graudal,Ramni Jamnadass,Jens-Peter B. Lilleso, Wubalem Tadesse, Joyce Chege,Fabio Pedercini,Soren Moestrup,Ian K. Dawson
ENVIRONMENTAL CONSERVATIONno. 4 (2023): 192-195
L. R. Rega, V. Janssens,J. H. Graversen,S. K. Moestrup, S. Cairoli,B. M. Goffredo,N. Nevo, G. E. Courtoy,F. Jouret,C. Antignac, F. Emma,C. E. Pierreux,P. J. Courtoy
Scientific reportsno. 1 (2023)
Vineesh Indira Chandran,Charlotte Wilhelmina Wernberg,Mette Munk Lauridsen,Maria Klojgaard Skytthe,Sofie Marchsteiner Bendixen,Frederik Tibert Larsen,Camilla Dalby Hansen,Lea Ladegaard Gronkjaer,Majken Storm Siersbaek,Tina Di Caterino,Sonke Detlefsen,Holger Jon Moller,Lars Grontved,Kim Ravnskjaer,Soren Kragh Moestrup,Maja Sofie Thiele,Aleksander Krag,Jonas Heilskov Graversen
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作者统计
#Papers: 355
#Citation: 24982
H-Index: 91
G-Index: 149
Sociability: 7
Diversity: 0
Activity: 1
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