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Our interests focus primarily upon enzymes that catalyse glycoside formation and hydrolysis, since these play crucial roles in all areas of biology. Applications of our research (see below) range from the development of new catalysts for industrial processes to the design, synthesis and testing of new therapeutics.
Understanding: Mechanistic studies are the foundation of our program and range from the discovery and analysis of “new” mechanisms by which enzymes catalyse these reactions through to development of a deeper understanding of how the enzymes for which we know the fundamental mechanisms achieve such enormous (107 fold) rate accelerations.
Inhibitors of glycosidases have value both as mechanistic probes and as potential diagnostics and therapeutics.
Engineering: a particular challenge in glycoscience is the efficient assembly of oligosaccharides and glycoproteins – especially on the large scale.
Understanding: Mechanistic studies are the foundation of our program and range from the discovery and analysis of “new” mechanisms by which enzymes catalyse these reactions through to development of a deeper understanding of how the enzymes for which we know the fundamental mechanisms achieve such enormous (107 fold) rate accelerations.
Inhibitors of glycosidases have value both as mechanistic probes and as potential diagnostics and therapeutics.
Engineering: a particular challenge in glycoscience is the efficient assembly of oligosaccharides and glycoproteins – especially on the large scale.
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