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For the last twenty five years Stephen Gillespie has been involved in various aspects of tuberculosis diagnosis and drug development. This has included the evaluation of new candidate antituberculosis agents in vitro. This work has expanded into studies of the molecular mechanisms of resistance and the development of model systems to measure the fitness deficits found in resistant strains. He has been involved in the development of fluoroquinolones for tuberculosis having performed early bacterial activity studies and clinical trials of ciprofloxacin. More recently he has led the group working on the clinical development of moxifloxacin in collaboration with the Global Alliance for TB Drug Development as Chief Investigator of the REMox TB study. He later went on to be the coordinating investigator for the TB Alliance STAND trial (Shortening Treatment by Advancing New Drugs) and SimpliciTB trial. He is also one of the Chief Investigators of the PanACEA consortium that links European and African research groups in enhancing anti-tuberculosis therapy.
研究兴趣
论文共 413 篇作者统计合作学者相似作者
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JOURNAL OF ANTIMICROBIAL CHEMOTHERAPYno. 3 (2024): 656-668
PLOS global public healthno. 2 (2024): e0002709-e0002709
Clinical Microbiology and Infectionno. 4 (2024): 481-488
Frontiers in pharmacology (2023): 1067295
medRxiv (Cold Spring Harbor Laboratory) (2023)
medrxiv(2023)
Pathogens (Basel, Switzerland)no. 2 (2023): 180-180
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