基本信息
浏览量:6
职业迁徙
个人简介
The B-cell receptor (BCR) serves two essential functions in B-cell activation, namely the initiation of signaling cascades that lead to the transcription of a variety of genes associated with B-cell activation and the transport of antigen to intracellular compartments, where the antigen is processed and presented on MHC class II molecules for recognition by helper T cells. Provided with the appropriate T-cell help following antigen contact, B cells proliferate and differentiate into short-lived, antibody-secreting plasma cells as well as long-lived plasma cells and memory B cells that constitute immunological memory. The long-range goal of the Lymphocyte Activation Section (LAS) is to gain an understanding of the cellular and molecular mechanisms that underlie the initiation of BCR signaling, the intracellular trafficking of the BCR, and the generation, maintenance, and activation of B-cell memory. Of particular interest is the regulation of these processes by B cell-activating and inhibitory co-receptors and during immune responses to infection. The long range goals of LAS are as follows:
Gain an understanding of the molecular mechanisms by which antigen engagement by BCR triggers a signaling cascade. A key element of this aim is the use of live-cell imaging techniques that allows analyses of the earliest events in the initiation of signaling that follow within seconds of the binding of the antigen to BCR at the single molecule level.
Determine the mechanisms that underlie the internalization and trafficking of BCR to MHC class II-containing intracellular compartments. These studies are defining the spatial relationship between the location of the BCR and the activation of various components of the signaling cascade, including the location of the interactions of the BCR with the intracellular innate immune system Toll-like receptors expressed by B cells that modulate BCR signaling.
Define the mechanisms that underlie the regulation of B-cell responses by the innate immune system receptors, including the Toll-like receptors, the activating receptor complex CD19/CD21, and the inhibitory receptor FcγRIIB.
Gain an understanding of the cellular mechanisms underlying the generation, maintenance, and activation of B cell immunological memory. These studies are focused on the acquisition and maintenance of memory in response to antigens of the malaria parasite Plasmodium falciparum, in response to vaccination in the United States and to natural infection in Africa.
研究兴趣
论文共 157 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Trialsno. 1 (2024): 1-17
Science signalingno. 804 (2023)
Pedro Felipe Gardeazabal Rodriguez, Yigal Lilach,Abhijit Ambegaonkar, Teresa Vitali,Haani Jafri,Hae Won Sohn,Matthew Dalva,Susan Pierce,Inhee Chung
Clare Cimperman,Mirna Pena, Sohret Gokcek,Brandon Theall, Meha Patel,Anisha Sharma,Chenfeng Qi,Daniel Sturdevant,Louis Miller,Patrick Collins,Susan Pierce,Munir Akkaya
biorxiv(2022)
Prasida Holla,Brian Dizon,Abhijit A Ambegaonkar, Noga Rogel,Ella Goldschmidt,Arun K Boddapati,Haewon Sohn,Dan Sturdevant,James W Austin,Lela Kardava, Li Yuesheng,Poching Liu,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn