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个人简介
Our research focusses on how human embryo develop and use of human embryonic stem cells (hESc) and induced pluripotent stem cells to understnd human development, for use in clinical cell-based therpy and for modeling human gnetic diseases. Human pluripotent stem cells (PSCs) can grow indefinitely in a dish while still retaining the ability to produce all the specialised cells in the body and hold great promise for cell therapy disease modeling and biopharma. 1) Work in our (HFEA-licenced) North West Embryonic Stem Cell Centre, in special clean culture rooms, concentrated on generating new hESc lines suitable for treating patients. We use these for a number of projects on human cell differention 2) Based on our novel highly efficient protocol to generate early stage chondrocytes from PSCs, we are working towards a new therapy for cartilage disease (e.g.osteoarthritis) employing PSC-derived chondrocytes and utilising our (HTA and MHRA licenced) clean rooms. 3) We investigate molecules in hPSCs which give them their special characteristics. 3) We are investigating the role of soluble and extracellular matrix derived secreted proteins in hPSCs. We have shown that particular extracellular matrix components and the cellular proteins they bind, are important in regulating stem cell properties and behaviour. 4) We have developed in vitro models for genetic diseases of the skeleton, the vasculature and the kidney. 5) We study regulation of the first few days of human embryo development and we also use the mouse as a model e.g. for placenta development.
研究兴趣
论文共 160 篇作者统计合作学者相似作者
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Leona Ogene,Steven Woods, Joseph Hetmanski,Neus Lozano, Angeliki Karakasidi,Patrick T. Caswell,Kostas Kostarelos,Marco A. N. Domingos,Sandra Vranic,Susan J. Kimber
Leona Ogene,Steven Woods, Joseph Hetmanski,Neus Lozano, Angeliki Karakasidi,Patrick T Caswell,Kostas Kostarelos,Marco A N Domingos,Sandra Vranic,Susan J Kimber
Nanoscaleno. 11 (2024): 5653-5664
Evgenii Martirosian,Sara Cuvertino,Terence Garner, Bridgious Walusimbi,Susan Kimber,Siddharth Banka,Adam Stevens
EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 723-724
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Sara Cuvertino,Terence Garner, Evgenii Martirosian, Bridgious Walusimbi,Susan J Kimber,Siddharth Banka,Adam Stevens
crossref(2024)
Scientific Reportsno. 1 (2024): 1-14
PloS oneno. 1 (2023): e0280024-e0280024
TISSUE ENGINEERING PART Ano. 13-14 (2023)
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TISSUE ENGINEERING PART Ano. 11-12 (2023): 1443-1444
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