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Professor Sorrell’s medical mycology research interests include: (a) basic research on the pathogenesis of invasive fungal infections using Cryptococcus neoformans as a model; (b) drug discovery; and (c) clinical and translational research. Her work has made major contributions to the understanding of cryptococcal disease in immunocompromised and immunocompetent hosts.
Prof Sorrell’s team identified phospholipase B (PLB) as a virulence determinant of C neoformans and its potential as a target for new drug development. Current work led by Dr Julie Djordjevic, Leader of the Fungal Pathogenesis Group, involves the study of other phospholipases in cryptococci, elucidating the secretory pathway of PLB using molecular techniques (as a basis for new drug development), and exploring the mechanisms by which cryptococci cross the blood-brain barrier to cause neurological disease. Molecular epidemiology research led by Professor Wieland Meyer employs genome sequencing to map determinants of habitat adaptation, virulence expression, clinical presentation and host response in cryptococcosis. Overall, the basic research program aims to understand geographic patterns of infection, identify new targets for diagnostic tests, and potential targets for therapeutic drugs and vaccines.
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