基本信息
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Career Trajectory
Bio
Bachelor's degree in Biology from the University of Oviedo in 1999, research proficiency in 2001and a doctorate degree in 2005, with a doctoral thesis that won the extraordinary doctorate award from the University of Oviedo. My work during the predoctoral training period was funded by two scholarships associated with national projects of the Ministry of Science and the Ministry of Health (FISS). 28-month postdoctoral stay at the MD Anderson Cancer Center (Houston, TX, USA) financed by two postdoctoral contracts obtained in regional and national calls. During my postdoctoral stay, I also obtained funding from the American Brain Tumor Association (ABTA). Reincorporation to the University of Oviedo, initially as a postdoctoral hired by the University Institute of Oncology, later with a contract grant for oncology researchers funded by the Spanish Association Against Cancer, and later with a postdoctoral contract with the Juan de la Cierva subprogram. Assistant Professor in the Department of Morphology and Cell Biology of the University of Oviedo from 2010 to 2015 and Associated Professor from 2015 to 2019. Currently I continue my work in the aforementioned department as Professor. From the beginning I have been very focused on the study of the antitumor activity of melatonin, with special interest in its effects on glioblastoma, describing for the first time its antitumor action in this type of tumor, not only on parenchymal cells but also and most importantly, on tumor stem cells. Of special interest we have described that melatonin, unlike the accepted antiproliferative action in a large number of tumors, is capable of inducing the death of specific tumor types such as Ewing's sarcoma, acute myeloid leukemia or tumor stem cells derived from glioblastoma. These cytotoxic effects are related to modifications in the cellular redox state as a consequence of alterations in cellular energy metabolism. At present I am especially interested in the implication of the endoplasmic reticulum in the different functions in tumor cells, since it is involved in both the regulation of the cellular redox state and the metabolic flexibility of tumors, with special attention to its involvement in the biology of gliomas, since it is known that current treatments against this type of tumor (temozolamide and kinase inhibitors) affect this organelle.
Research Interests
Papers共 109 篇Author StatisticsCo-AuthorSimilar Experts
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Hematological oncologyno. 3 (2024)
Jezabel Rodriguez-Blanco,April D. Salvador,Robert K. Suter,Marzena Swiderska-Syn, Isabel Palomo-Caturla, Valentin Kliebe, Pritika Shahani, Kendell Peterson,Maria Turos-Cabal, Megan E. Vieira,Daniel T. Wynn, Ashley J. Howell, Fan Yang,Yuguang Ban,Heather J. McCrea,Frederique Zindy,Etienne Danis,Rajeev Vibhakar,Anna Jermakowicz,Vanesa Martin,Christopher C. Coss,Brent T. Harris,Aguirre de Cubas,X. Steven Chen,Thibaut Barnoud,Martine F. Roussel,Nagi G. Ayad,David J. Robbins
JOURNAL OF CLINICAL INVESTIGATIONno. 15 (2024)
HemaSphereno. S3 (2023)
Mickael Diallo, Constanca Pimenta,Fernanda Murtinheira, Daniela Martins-Alves, Francisco R. Pinto, Andre Abrantes da Costa,Ricardo Letra-Vilela,Vanesa Martin,Carmen Rodriguez,Mario S. Rodrigues,Federico Herrera
Cellular oncology (2023)
Noelia Puente‐Moncada,Paula Costales, Isaac Antolı́n,Luz-Elena Núñez, Patricia Oro, Maria Ana Hermosilla, Jhudit Pérez‐Escuredo,Nicolás Ríos-Lombardía,Ana M. Sánchez‐Sánchez, Elisa Luño, Carmen Rodríguez,Vanesa Martı́n,Francisco Morís
openalex(2023)
Xabier Agirre,Amaia Vilas-Zornoza,Antonio Jiménez-Velasco,José Ignacio Martin-Subero,Lucia Cordeu,Leire Gárate,Edurne San José-Eneriz,Gloria Abizanda,Paula Rodríguez-Otero,Puri Fortes,José Rifón,Eva Bandrés,María José Calasanz,Vanesa Martín,Anabel Heiniger,Antonio Torres,Reiner Siebert,José Román-Gomez,Felipe Prósper
crossref(2023)
Xabier Agirre,Amaia Vilas-Zornoza,Antonio Jiménez-Velasco,José Ignacio Martin-Subero,Lucia Cordeu,Leire Gárate,Edurne San José-Eneriz,Gloria Abizanda,Paula Rodríguez-Otero,Puri Fortes,José Rifón,Eva Bandrés,María José Calasanz,Vanesa Martín,Anabel Heiniger,Antonio Torres,Reiner Siebert,José Román-Gomez,Felipe Prósper
crossref(2023)
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Author Statistics
#Papers: 109
#Citation: 5197
H-Index: 32
G-Index: 72
Sociability: 7
Diversity: 0
Activity: 1
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