基本信息
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个人简介
28 years old
PhD student at University of Beira Interior (Chemistry)
Researcher at CICS-UBI - Health Sciences Research Centre of University of Beira Interior
Teaching Assistant at Chemistry Department of Faculty of Sciences (UBI)
AREA OF SCIENTIFIC ACTIVITY
Scientific Domain
Organic, computational and medicinal chemistry.
Scientific and Research Interests
o Planned and rational synthesis and biological evaluation of potential bioactive compounds;
o Prediction of interaction and affinity between chemical compounds and potential biological targets.
Skills
o Chemical synthesis of steroid derivatives;
o Cell culture of human tumoral and healthy cell lines (MCF-7, T-47D, LNCaP, PC-3, Caco-2 and NHDF).
o Study of chemical compounds’ effects on cellular proliferation, using human cell cultures (MTT and resazurin assays, flow cytometry, fluorescence microscopy);
o Protein Quantification;
o Regarding to computational chemistry in drug development process and design: experience with MarvinSketch, ChemWindow, ChemDraw, Marvin, AutodockTools, Chimera, Gaussian, Avogadro, PyMol, PyRx, Modeller, Jalview and Vega ZZ.
• Bachelor final year research project: “Inibidores da biossíntese de androgénios – Síntese e avaliação biológica computacional”
Advisor: Professor Samuel Silvestre, PhD
• Research dissertation (to obtain master degree): “Development of novel 4-azasteroid derivatives as potential 5α-reductase inhibitors: synthesis, biological and computational evaluation”.
Advisor: Professor Samuel Silvestre, PhD.
Other skills
o Knowledge and experience of Windows operative system, macOS, Microsoft Office and GraphPad.
Scientific Events Organization
o IV Jornadas de Química e Bioquímica – 4th and 5th May 2016, organized by Core of Chemistry Students of University of Beira Interior (UBIQuímica);
o III Jornadas de Química e Bioquímica – 6th and 7th May 2015, organized by Core of Chemistry Students of University of Beira Interior (UBIQuímica);
o Junior Chemistry Olympiad 2015 – 13th April 2013, promoted by Portuguese Chemistry Society (SPQ - http://www.spq.pt )
研究兴趣
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Biomedicinesno. 3 (2023): 812-812
Journal of inorganic biochemistry (2020): 111331-111331
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