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个人简介
Dr. Nizet’s laboratory interests lie in understanding the fundamental mechanisms of bacterial pathogenesis and the innate immune system, with a special focus on invasive and antibiotic-resistant pathogens. Using a variety of molecular genetic approaches, the laboratory discovers and characterizes bacterial virulence factors involved in cytotoxicity, adherence, invasion, inflammation, molecular mimicry and resistance to immunologic clearance. In companion studies, we investigate the contribution of host factors such as antimicrobial peptides, leukocyte surface receptors, signal transduction pathways, and transcription factors in defense against invasive bacterial infection.
We have shown that the basic information gained through this platform can lead to novel treatment strategies for infectious diseases, involving targeted neutralization of bacterial virulence phenotypes and pharmacologic boosting of host innate immune cell function and drug repurposing. Additional studies examine innovative nano therapeutic and vaccine approaches to prevent infection by leading pathogens.\
Awards and Honors: American Lung Associate Career Investigator Award (2004); American Heart Association Established Investigator Award (2004); American Society for Clinical Investigation (2006); E. Mead Johnson Award for Research in Pediatrics (2008); American Asthma Foundation Senior Investigator Award (2008); Fellow, American Academy of Microbiology (2012). UCSD Chancellor’s Award for Excellence in Postdoctoral Fellow Mentoring (2013), UCSD Chancellor's Associates Award for Excellence in Research in Science and Engineering (2017). UCSD Health Sciences Award for Excellence in Faculty Mentoring (2018), NIH Merit Award (2019), American Society of Microbiology DC White Award for Interdiscipinary Research and Mentoring (2022)
研究兴趣
论文共 431 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biologyno. 3 (2024): 619-628
Xue Liu,Laurye Van Maele,Laura Matarazzo, Daphnée Soulard, Vinicius Alves Duarte da Silva,Vincent de Bakker,Julien Dénéréaz,Florian P Bock,Michael Taschner, Jinzhao Ou,Stephan Gruber,Victor Nizet,
Cell host & microbeno. 3 (2024): 304-314.e8
JOURNAL OF CLINICAL MICROBIOLOGYno. 1 (2024): e0036623-e0036623
Jacinda C. Abdul-Mutakabbir, Nana Sakyi Opoku,Karen K. Tan,Peter Jorth,Victor Nizet,Hansel M. Fletcher,Keith S. Kaye,Michael J. Rybak, William R. Schwan
ANTIBIOTICS-BASELno. 1 (2024): 47
Elisabet Bjanes, Truman Koh, Tariq Qayum,Raymond Zurich, Sinead Mccabe, Kegan Hampel, Lisa Cartwright,Victor Nizet
ANTIBIOTICS-BASELno. 1 (2024): 10
Yue Zhang,Vanthana Bharathi,Tatsuya Dokoshi,Jaime de Anda, Lauryn Tumey Ursery,Nikhil N. Kulkarni, Yoshiyuki Nakamura,Jonathan Chen, Elizabeth W. C. Luo,Lamei Wang, Hua Xu,Alison Coady,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 6 (2024): e2300644120-e2300644120
Alexandria Hoffman,Victor Nizet
The Journal of pharmacology and experimental therapeuticspp.JPET-MR, (2024)
Vicki Mercado-Evans, Claude Chew, Camille Serchejian,Alexander Saltzman,Marlyd E Mejia,Jacob J Zulk,Ingrid Cornax,Victor Nizet,Kathryn A Patras
bioRxiv : the preprint server for biology (2024)
The Journal of biological chemistrypp.104980, (2023)
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JOURNAL OF BIOLOGICAL CHEMISTRYno. 8 (2023): 104980-104980
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