基本信息
浏览量:98
职业迁徙
个人简介
Research
My current research activities focus on the preclinical and clinical development of vaccines designed to prevent adult-onset cancers such as breast cancer, ovarian cancer, and endometrial cancer. My prototypic strategy for developing cancer prevention vaccines is based on the “retired self-protein hypothesis" whereby tissue-specific proteins that are no longer expressed in normal tissues as a result of the natural aging process may induce safe and effective prophylactic vaccination against age-related emerging tumors that express the targeted “retired” protein. We are currently involved in a phase I clinical trial sponsored by the U.S. Department of Defense to determine the safety and dosage of a vaccine ultimately designed to prevent triple negative breast cancer (TNBC), the most aggressive and lethal form of breast cancer and the version of breast cancer that predominates in women at high genetic risk due to carrying mutations in their BRCA1 genes. We also have a collaborative agreement with the National Cancer Institute’s PREVENT Program to enter clinical trials ultimately designed to determine the ability of our ovarian cancer vaccine to prevent ovarian cancer and endometrial cancer. Supporting all of this publicly supported work are licensing agreements with Anixa Biosciences, Inc. to facilitate commercialization of these two vaccines. Finally, my program has also developed a humanized monoclonal antibody that inhibits the growth of human ovarian tumors in patient-derived xenografts and may be useful in treating human ovarian and endometrial cancers either directly or as an immune reagent for delivering a toxic payload to tumor cells.
My current research activities focus on the preclinical and clinical development of vaccines designed to prevent adult-onset cancers such as breast cancer, ovarian cancer, and endometrial cancer. My prototypic strategy for developing cancer prevention vaccines is based on the “retired self-protein hypothesis" whereby tissue-specific proteins that are no longer expressed in normal tissues as a result of the natural aging process may induce safe and effective prophylactic vaccination against age-related emerging tumors that express the targeted “retired” protein. We are currently involved in a phase I clinical trial sponsored by the U.S. Department of Defense to determine the safety and dosage of a vaccine ultimately designed to prevent triple negative breast cancer (TNBC), the most aggressive and lethal form of breast cancer and the version of breast cancer that predominates in women at high genetic risk due to carrying mutations in their BRCA1 genes. We also have a collaborative agreement with the National Cancer Institute’s PREVENT Program to enter clinical trials ultimately designed to determine the ability of our ovarian cancer vaccine to prevent ovarian cancer and endometrial cancer. Supporting all of this publicly supported work are licensing agreements with Anixa Biosciences, Inc. to facilitate commercialization of these two vaccines. Finally, my program has also developed a humanized monoclonal antibody that inhibits the growth of human ovarian tumors in patient-derived xenografts and may be useful in treating human ovarian and endometrial cancers either directly or as an immune reagent for delivering a toxic payload to tumor cells.
研究兴趣
论文共 134 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Cancer researchno. 5_Supplement (2023): OT2-02
George Thomas Budd,Justin M. Johnson, Emily Rhoades,Halle Moore, Holly Levengood,Megan Kruse,Erin Roesch,Jame Abraham,Brenna Elliott, Elena Haury, Rachel Swartz,Holly Pederson,Zahraa Al Hilli,Vincent Tuohy
Cancer Researchno. 7_Supplement (2023): 3035-3035
G. Thomas Budd,Justin M. Johnson, Emily E. Rhoades,Halle C. F. Moore, Megan Kruse, Erin Roesch,Jame Abraham, Brenna Elliott, Donna Lach,Vincent K. Tuohy
Journal of clinical oncologyno. 16_suppl (2022): TPS1125-TPS1125
George Thomas Budd,Justin M. Johnson, Emily Esakov Rhoades,Halle C. F. Moore,Megan Lynn Kruse,Erin Elizabeth Roesch,Jame Abraham,Brenna Elliott, Donna Lach,Vincent K. Tuohy
加载更多
作者统计
#Papers: 134
#Citation: 8824
H-Index: 48
G-Index: 93
Sociability: 6
Diversity: 0
Activity: 0
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn