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My lab studies the function and regulation of the Mdm2-p53 tumor suppression pathway
In vivo function of Mdm2 E3 ubiquitin ligase in p53 regulation
The tumor suppressor p53 is a critical mediator of the cellular stress response, maintaining genomic integrity and preventing oncogenic transformation. Mdm2, the primary negative regulator for p53, controls p53 through functioning as an E3 ubiquitin ligase targeting p53 for proteasomal degradation. Our recent studies with mouse models expressing knock-in mutant Mdm2 have revealed a surprisingly dispensable nature for the Mdm2 E3 ligase under unstressed conditions. We are interested in defining the function of Mdm2 in p53 regulation, thereby providing insight into the Mdm2-p53 regulatory loop and solutions to the current problems surrounding the development of effective cancer therapeutics targeting the p53 pathway.
My lab studies the function and regulation of the Mdm2-p53 tumor suppression pathway
In vivo function of Mdm2 E3 ubiquitin ligase in p53 regulation
The tumor suppressor p53 is a critical mediator of the cellular stress response, maintaining genomic integrity and preventing oncogenic transformation. Mdm2, the primary negative regulator for p53, controls p53 through functioning as an E3 ubiquitin ligase targeting p53 for proteasomal degradation. Our recent studies with mouse models expressing knock-in mutant Mdm2 have revealed a surprisingly dispensable nature for the Mdm2 E3 ligase under unstressed conditions. We are interested in defining the function of Mdm2 in p53 regulation, thereby providing insight into the Mdm2-p53 regulatory loop and solutions to the current problems surrounding the development of effective cancer therapeutics targeting the p53 pathway.
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