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After completing my undergraduate and graduate work at Shanxi Medical University in Taiyuan, China, I attended the Peking Union Medical College and Chinese Academy of Medical Sciences at Beijing and received my Ph.D. in 2003. I joined the lab of professor Shih-Hsin Lu in the cancer institute of Peking Union Medical College and Chinese Academy of Medical Sciences, and my initial focus was identifying and functional study of esophage carcinoma-related genes from Chinese patients. By using DDPCR, we identified four novel candidates of tumor-suppressor gene from human esophagus. Esophageal cancer-related gene 2 (ECRG2) is one of them. Our preliminary study showed that ECRG2 in esophageal cancer cells act as a bifunctional protein associated with regulation of cell proliferation and induction of apoptosis. By using yeast two-hybrid screen of a human fetal liver cDNA library, we identified nine putative clones as associated proteins. ECRG2 was negatively associated with MT2A in the regulation of cell proliferation and induction of apoptosis. The physical interaction of ECRG2 and metallothionein 2A may play important role in carcinogenesis of esophageal cancer. I later completed my postdoctoral work at both the University of Michigan Medical School and the H. Lee Moffitt Cancer Center and Research Institute.
Currently, I am a professor at the Shanxi Medical University. My lab focuses on the study of cancer, especially the functional study of the ECRG2 gene. We have shown that the ECRG2 gene is important for ensuring centrosome duplication, spindle assembly checkpoint, and accurate chromosome segregation, and its depletion may contribute to chromosome instability and aneuploidy in human cancers. In this paper, we showed that ECRG2 is involved in the regulation of migration/invasion through uPA/uPAR/β1 integrins/Src/MAP kinase pathway and may represent a novel therapeutic target for cancer.
Currently, I am a professor at the Shanxi Medical University. My lab focuses on the study of cancer, especially the functional study of the ECRG2 gene. We have shown that the ECRG2 gene is important for ensuring centrosome duplication, spindle assembly checkpoint, and accurate chromosome segregation, and its depletion may contribute to chromosome instability and aneuploidy in human cancers. In this paper, we showed that ECRG2 is involved in the regulation of migration/invasion through uPA/uPAR/β1 integrins/Src/MAP kinase pathway and may represent a novel therapeutic target for cancer.
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Xuehan Zhuang,Rui Ye,Yong Zhou, Matthew Yibo Cheng,Heyang Cui,Longlong Wang,Shuangping Zhang,Shubin Wang,Yongping Cui,Weimin Zhang
Genome Medicineno. 1 (2024): 1-19
CANCER GENE THERAPYno. 1 (2024): 131-147
Medical Reviewno. 0 (2024)
Zhihuai Liu,Yahui Zhao,Pengzhou Kong,Yuhao Liu,Jing Huang,Enwei Xu,Wenqing Wei, Guangyu Li,Xiaolong Cheng,Liyan Xue,Yi Li,Hongyan Chen,
CANCER CELLno. 1 (2023): 181-+
Ting Yan, Lili Liu,Meilan Peng,Zhenpeng Yan, Qingyu Wang,Shan Zhang,Lu Wang,Xiaofei Zhuang,Huijuan Liu,Yanchun Ma,Bin Wang,Yongping Cui
Research Square (Research Square) (2021)
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