Lanosterol reverses protein aggregation in cataracts

Ling Zhao,Xiang-Jun Chen,Jie Zhu,Yi-Bo Xi,Xu Yang,Li-Dan Hu,Hong Ouyang,Sherrina H. Patel,Xin Jin,Danni Lin,Frances Wu,Ken Flagg,Huimin Cai,Gen Li,Guiqun Cao,Ying Lin,Daniel Chen,Cindy Wen,Christopher Chung, Yandong Wang, Austin Qiu,Emily Yeh,Wenqiu Wang,Xun Hu, Seanna Grob,Ruben Abagyan, Zhiguang Su,Harry Christianto Tjondro,Xi-Juan Zhao,Hongrong Luo,Rui Hou, J. Jefferson, P. Perry,Weiwei Gao, Igor Kozak, David Granet,Yingrui Li,Xiaodong Sun,Jun Wang,Liangfang Zhang,Yizhi Liu,Yong-Bin Yan,Kang Zhang

Nature（2015）

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摘要

Exploring the genetic basis of congenital cataracts in two families identifies a molecule, lanosterol, which prevents intracellular protein aggregation of various cataract-causing mutant crystallins, and which can reduce cataract severity and increase lens transparency in vivo in dogs.

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关键词

Genetics research,Mechanisms of disease,Translational research,Vision disorders,Science,Humanities and Social Sciences,multidisciplinary

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