Inhibition of RAS function through targeting an allosteric regulatory site

NATURE CHEMICAL BIOLOGY（2016）

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摘要

monobody was identified that binds to an allosteric lobe at the α4-β6-α5 interface to block H- and K-RAS signaling and transformation by disrupting RAS dimerization and nanoclustering.

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关键词

Cell signalling,Kinases,Protein design,X-ray crystallography,Cancer

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