Abnormal cortical functional activity in patients with ischemic white matter lesions: A resting-state functional magnetic resonance imaging study.

•We examine the relationship between WMLs and cognitive function using a ReHo method.•Abnormal regions are related to memory, attention and executive and motor function.•Altered regions in the DMN, FPCN and motor area correlate with cognitive test scores.•The findings improve our understanding of pathophysiological mechanisms of WMLs.