Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion

Chiman Song,Yeonju Bae, Jin Joo Jun,Hyomin Lee,Nam Doo Kim,Kyung Bok Lee,Wooyoung Hur,Jae-Yong Park,Taebo Sim

Biochimica et Biophysica Acta (BBA) - General Subjects（2017）

引用 41|浏览16

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摘要

•TR-FRET based TRPM7 kinase assay was established with CREB peptide as a substrate.•TG100-115 has potent TRPM7 kinase inhibitory activity.•TG100-115 suppresses migration and invasion of triple negative breast cancer cells.•TG100-115 suppresses channel activity of TRPM7.

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关键词

TRPM7 kinase inhibitor,TG100-115,MDA-MB-231,Breast cancer,Cell migration,Cell invasion

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