De novo generation of a functional human thymus from induced pluripotent stem cells.

Amiet R Chhatta,Martijn Cordes,Maaike A J Hanegraaf,Sandra Vloemans,Tom Cupedo,Jan J Cornelissen,Francoise Carlotti,Daniela Salvatori,Karin Pike-Overzet,Willem E Fibbe,Rob C Hoeben,Harald M M Mikkers,Frank J T Staal

Journal of Allergy and Clinical Immunology（2019）

引用 26|浏览38

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摘要

Patient-specific, human thymus organoids that support de novo T cell development may lead to new therapeutic options for diseases with severely diminished thymic function.

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关键词

DiGeorge Syndrome,Organoid,gene therapy,iPSC,thymus

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