Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands.

Matthew C Clifton,Peter B Rupert,Trisha M Hoette,Kenneth N Raymond大牛学者,Rebecca J Abergel,Roland K Strong

Journal of Structural Biology: X（2019）

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摘要

•Ligand recognition by antibacterial Siderocalin controls the competition for iron during infection.•We determined nine crystal structures of Siderocalin mutants with ligands.•We determined three candidate ligands did not bind.•We determined the crystal structure of SBP YfiY.•Multiplexed specificity of Siderocalin was determined.

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关键词

AEB,ABC,AU,BOCT,c-di-GMP,CAM,CMB,DHBA,ENT,FQ,HOPO,NGAL,NE,PBP,PDB,PCH,PVD,SBP,SCH,Scn

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