The role of IL-32 in Bacillus Calmette-Guérin (BCG)-induced trained immunity in infections caused by different Leishmania spp.

Muriel Vilela Teodoro Silva,Jéssica Cristina Dos Santos,Ana Marina Barroso de Figueiredo,Lisa U Teufel,Jonathas Xavier Pereira,Grazzielle Guimarães de Matos,Sebastião Alves Pinto,Mihai G Netea,Rodrigo Saar Gomes,Leo A B Joosten,Fátima Ribeiro-Dias

Microbial Pathogenesis（2021）

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摘要

•BCG-trained monocytes presented enhanced ability to kill Leishmania spp.•IL-32 appears to play an essential role in the development of trained immunity.•BCG reduced the parasite load in experimental leishmaniasis.•IL-32γ increases the protective effects of BCG-induced training in vivo.

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关键词

Leishmania,Human,IL-32γTg mouse,BCG,IL-32

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