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On-line duplex molecularly imprinted solid-phase extraction for analysis of low-abundant biomarkers in human serum by liquid chromatography-tandem mass spectrometry

Nicholas McKitterick,Tugrul Cem Bicak,Magdalena A. Switnicka-Plak,Peter A.G. Cormack,Léon Reubsaet,Trine Grønhaug Halvorsen

Journal of Chromatography A（2021）

Cited 7|Views24
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Abstract
•Determination of two low-abundant small cell lung cancer biomarkers.•Molecularly imprinted polymers (MIPs) targeting tryptic peptides.•MIPs combined for duplex on-line extraction prior to LC MS/MS.•Target peptides successfully captured from trypsin-digested human serum.•Improved extraction performance compared to single-plex methods.
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Key words
On-line SPE,Multiplexing,Molecularly imprinted polymers,LC-MS/MS,Low-abundant biomarkers,Targeted bottom-up proteomics
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